Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 772

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Analgesia from Electrical Stimulation in the Brainstem of the Rat

Mayer, David J., Wolfle, Thomas L., Akil, Huda, Carder, Brooks, Liebeskind, John C.·1971·Science
DOI 10.1126/science.174.4016.1351
Open this paper in CoChat — free account

Abstract

Stimulation at several mesencephalic and diencephalic sites abolished responsiveness to intense pain in rats while leaving responsiveness to other sensory modes relatively unaffected. The peripheral field of analgesia was usually restricted to one-half or to one quadrant of the body, and painful stimuli applied outside this field elicited a normal reaction. Analgesia outlasted stimulation by up to 5 minutes. Most electrode placements that produced analgesia also supported self-stimulation. One placement supported self-stimulation only in the presence of pain.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.174.4016.1351

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 17

  1. BECKER, D.P., AN INQUIRY INTO NEUROPHYSIOLOGICAL BASIS FOR PAIN, JOURNAL OF NEUROSURGERY 30: 1 (1969). · doi:10.3171/jns.1969.30.1.0001
  2. BREGLIO, V, ALTERATION IN FOOTSHOCK THRESHOLD BY LOW-LEVEL SEPTAL BRAIN STIMULATATION, PHYSIOLOGY & BEHAVIOR 5: 715 (1970). · DOI
  3. COX, V.C., ATTENUATION OF AVERSIVE PROPERTIES OF PERIPHERAL SHOCK BY HYPOTHALAMIC STIMULATION, SCIENCE 149: 323 (1965). · DOI
  4. ERVIN, F.R., PROCEEDINGS OF THE AMERICAN PSYCHOPATHOLOGICAL ASSOCIATION 58: 54 (1968).
  5. FOSTER, R.S., A COMPARISON OF PHARMACOLOGIC EFFECTS OF MORPHINE AND N-METHYL MORPHINE, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 157: 185 (1967).
  6. GOL, A, RELIEF OF PAIN BY ELECTRICAL STIMULATION OF SEPTAL AREA, JOURNAL OF THE NEUROLOGICAL SCIENCES 5: 115 (1967). · DOI
  7. Heath, R. G., Electrical Studies on the Unanesthetized Brain: 214 (1960).
  8. HERZ, A, CENTRAL SITES FOR ANTINOCICEPTIVE ACTION OF MORPHINE AND FENTANYL, NEUROPHARMACOLOGY 9: 539 (1970). · DOI · Paper page
  9. LIEBESKIND, J.C., SOMATOSENSORY EVOKED RESPONSES IN MESENCEPHALIC CENTRAL GRAY MATTER OF RAT, BRAIN RESEARCH 27: 133 (1971). · DOI
  10. LOTTI, V.J., TEMPERATURE RESPONSES IN RAT FOLLOWING INTRACEREBRAL MICROINJECTION OF MORPHINE, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 150: 135 (1965).
  11. 10.1126/science.150.3699.971 · DOI · Paper page
  12. Melzack, R., The Skin Senses: 423 (1968).
  13. 10.1126/science.164.3878.444 · DOI · Paper page
  14. SATOH, M, ENHANCEMENT BY MORPHINE OF CENTRAL DESCENDING INHIBITORY INFLUENCE ON SPINAL SENSORY TRANSMISSION, EUROPEAN JOURNAL OF PHARMACOLOGY 14: 60 (1971). · doi:10.1016/0014-2999(71)90122-1
  15. TSOU, K, STUDIES ON SITE OF ANALGESIC ACTION OF MORPHINE BY INTRACEREBRAL MICRO-INJECTION, SCIENTIA SINICA 13: 1099 (1964).
  16. Way, E. L., Narcotic Drugs, Biochemical Pharmacology: 229 (1971).
  17. WOLFLE, T.L., MOTIVATIONAL EFFECTS OF ELECTRICAL STIMULATION IN DORSAL TEGMENTUM OF RAT, PHYSIOLOGY & BEHAVIOR 7: 569 (1971). · DOI

Cited by

See all 772

Metadata

Authors
Mayer, D. J., Wolfle, T. L., Akil, H., Carder, B., & Liebeskind, J. C.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1971-12-24
Volume
174
Issue
4016
Pages
1351-1354
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.174.4016.1351
OpenAlex
W2048712968
Cited by
772
References
1
FWCI
18.01
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Analgesia from Electrical Stimulation in the Brainstem of the Rat. https://app.cochat.ai/papers/10.1126/science.174.4016.1351
The paper
Mayer, D. J., Wolfle, T. L., Akil, H., Carder, B., & Liebeskind, J. C. (1971). Analgesia from Electrical Stimulation in the Brainstem of the Rat. Science. https://doi.org/10.1126/science.174.4016.1351

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.