The DOI matches its Crossref record.
A Fungal Gene for Antibiotic Resistance on a Dispensable ("B") Chromosome
Abstract
A family of cytochrome P-450 ( Pda ) genes in the pathogenic fungus Nectria haematococca is responsible for the detoxification of the phytoalexin pisatin, an antimicrobial compound produced by garden pea ( Pisum sativum L.). The Pda6 gene was mapped by electrophoretic karyotype analysis to a small meiotically unstable chromosome that is dispensable for normal growth. Such traits are typical of B chromosomes. The strains of Nectria studied here have no sequences that are homologous to the Pda family other than Pda6 and therefore demonstrate that unique, functional genes can be found on B chromosomes. Unstable B chromosomes may be one mechanism for generating pathogenic variation in fungi.
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Cited by
Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution
Todd, R. T., Forche, A., & Selmecki, A. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0051-2016 · Cited by 121
A Double-Edged Sword: Aneuploidy is a Prevalent Strategy in Fungal Adaptation
Tsai, H.-J., & Nelliat, A. (2019) · Genes · doi:10.3390/genes10100787 · Cited by 60
Metadata
- Authors
- Miao, V. P., Covert, S. F., & VanEtten, H. D.
- Venue
- Science
- Published
- 1991-12-20
- Volume
- 254
- Issue
- 5039
- Pages
- 1773-1776
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014732701
- Cited by
- 283
- References
- 0
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
