The DOI matches its Crossref record.
Maintenance of Normoglycemia in Diabetic Mice by Subcutaneous Xenografts of Encapsulated Islets
Abstract
The goal of islet transplantation in human diabetes is to maintain the islet grafts in the recipients without the use of immunosuppression. One approach is to encapsulate the donor islets in permselective membranes. Hollow fibers fabricated from an acrylic copolymer were used to encapsulate small numbers of rat islets that were immobilized in an alginate hydrogel for transplantation in diabetic mice. The fibers were biocompatible, prevented rejection, and maintained normoglycemia when transplanted intraperitoneally; hyperglycemia returned when the fibers were removed at 60 days. Normoglycemia was also maintained by subcutaneous implants that had an appropriately constructed outer surface on the fibers.
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Citations
Cited by
Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893
Technology of mammalian cell encapsulation
Uludag, H., De Vos, P., & Tresco, P. A. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00053-3 · Cited by 601
Implantable biohybrid artificial organs
Colton, C. (1995) · Cell Transplantation · doi:10.1016/0963-6897(95)00025-s · Cited by 586
Host response to tissue engineered devices
Babensee, J. E., Anderson, J. M., McIntire, L. V., & Mikos, A. G. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(98)00023-4 · Cited by 585
Neovascularization of synthetic membranes directed by membrane microarchitecture
Brauker, J. H., Carr‐Brendel, V. E., Martinson, L. A., Crudele, J., Johnston, W. D., & Johnson, R. C. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820291208 · Cited by 517
Metadata
- Authors
- Lacy, P. E., Hegre, O. D., Gerasimidi-Vazeou, A., Gentile, F. T., & Dionne, K. E.
- Venue
- Science
- Published
- 1991-12-20
- Volume
- 254
- Issue
- 5039
- Pages
- 1782-1784
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994180851
- Cited by
- 345
- References
- 0
- FWCI
- 20.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Maintenance of Normoglycemia in Diabetic Mice by Subcutaneous Xenografts of Encapsulated Islets. https://app.cochat.ai/papers/10.1126/science.1763328
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- Lacy, P. E., Hegre, O. D., Gerasimidi-Vazeou, A., Gentile, F. T., & Dionne, K. E. (1991). Maintenance of Normoglycemia in Diabetic Mice by Subcutaneous Xenografts of Encapsulated Islets. Science. https://doi.org/10.1126/science.1763328
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
