Neovascularization of synthetic membranes directed by membrane microarchitecture
Abstract
Transplantation of tissues enclosed within a membrane device designed to protect the cells from immune rejection (immunoisolation) provides an opportunity to treat a variety of disease conditions. Successful implementation of immunoisolation has been hampered by the foreign‐body reaction to biomaterials. We screened a variety of commercially available membranes for foreign‐body reactions following implantation under the skin of rats. Histologic analysis revealed that neovascularization at the membrane–tissue interface occurred in several membranes that had pore sizes large enough to allow complete penetration by host cells (0.8‐8‐μm pore size). When the vascularization of the membrane–tissue interface of 5‐μm‐pore‐size polytetrafluoroethylene (PTFE) membranes was compared to 0.02‐μm‐pore‐size PTFE membranes, it was found that the larger pore membranes had 80–100‐fold more vascular structures. The increased vascularization was observed even though the larger pore membrane was laminated to a smaller pore inner membrane to prevent cell entry into the prototype immunoisolation device. This significantly higher level of vascularization was maintained for 1 year in the subcutaneous site in rats. © 1995 John Wiley & Sons, Inc.
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Upon rat subdermal implantation, PTFE membranes with 5 μm pore size provided 80-100 times more vascular structures than membranes with 0.02 μm pore size.
“Upon rat subdermal implantation, larger pore membranes provided 80–100 times more vascular structures.”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [140]
Increased vascularization correlated with the ability of inflammatory cells to infiltrate the porous membrane.
“this increased vascularization correlated with the ability of inflammatory cells to infiltrate the porous membrane.”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [155]
Membranes with larger pores (5.0 versus 0.02 μm) had 80-100 times greater vascularization in the surrounding tissue.
“Membranes fabricated with the larger pores were characterized by 80–100x greater vascularization in the tissue surrounding the implant.”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [155]
Membranes with larger pores also showed increased vascularization at one year.
“The membranes with the larger pores also showed increased vascularization at the one year mark.”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [155]
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- Authors
- Brauker, J. H., Carr‐Brendel, V. E., Martinson, L. A., Crudele, J., Johnston, W. D., & Johnson, R. C.
- Affiliations
- Baxter (United States) (US)
- Corresponding author
- Brauker, James H.
- ORCID
- Johnson, Robert C.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 29
- Issue
- 12
- Pages
- 1517-1524
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W1967264939
- Cited by
- 517
- References
- 0
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 14 · 2023: 12 · 2022: 8 · 2021: 16 · 2020: 25 · 2019: 22 · 2018: 26 · 2017: 25 · 2016: 21 · 2015: 20 · 2014: 18 · 2013: 25 · 2012: 21
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- neovascularization, synthetic membranes, pore size, polytetrafluoroethylene membrane, immunoisolation, foreign body reaction, biomaterial implantation, subcutaneous implantation, vascularization
- MeSH terms
- Animals, Biocompatible Materials, Blood Vessels, Foreign-Body Reaction, Male, Membranes, Artificial, Polytetrafluoroethylene, Porosity, Rats, Sprague-Dawley, Neovascularization, Physiologic, Prostheses and Implants, Rats
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