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A Binding Protein for Fatty Acids in Cytosol of Intestinal Mucosa, Liver, Myocardium, and Other Tissues
Abstract
A protein of molecular weight ∼ 12,000 which binds long-chain fatty acids and certain other lipids has been identified in cytosol of intestinal mucosa, liver, myocardium, adipose tissue, and kidney. Binding is noncovalent and is greater for unsaturated than for saturated and medium-chain fatty acids. This protein appears to be identical with the smaller of two previously described cytoplasmic anion-binding proteins. Binding of long-chain fatty acids by this protein is greater than that of other anions tested, including sulfobromophthalein, and does not depend on negative charge alone. The presence of this binding protein may explain previously observed differences in intestinal absorption among fatty acids, and the protein may participate in the utilization of long-chain fatty acids by many mammalian tissues.
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Cited by
Olsson, B., Lautner, R., Andreasson, U., Öhrfelt, A., Portelius, E., Bjerke, M., Hölttä, M., Rosén, C., Olsson, C., Strobel, G., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00070-3 · Cited by 2,049
Lipids and Lipid-Based Formulations: Optimizing the Oral Delivery of Lipophilic Drugs
Porter, C. J. H., Trevaskis, N. L., & Charman, W. N. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2197 · Cited by 1,824
Medium-chain triglycerides: an update
Bach, A., & Babayan, V. (1982) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.5.950 · Cited by 1,151
Metabolic functions of FABPs—mechanisms and therapeutic implications
Hotamisligil, G. S., & Bernlohr, D. A. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.122 · Cited by 712
Wolfrum, C., Borrmann, C. M., Börchers, T., & Spener, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051619898 · Cited by 503
Metadata
- Authors
- Ockner, R. K., Manning, J. A., Poppenhausen, R. B., & Ho, W. K. L.
- Venue
- Science
- Published
- 1972-07-07
- Volume
- 177
- Issue
- 4043
- Pages
- 56-58
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050353671
- Cited by
- 721
- References
- 0
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Binding Protein for Fatty Acids in Cytosol of Intestinal Mucosa, Liver, Myocardium, and Other Tissues. https://app.cochat.ai/papers/10.1126/science.177.4043.56
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- Ockner, R. K., Manning, J. A., Poppenhausen, R. B., & Ho, W. K. L. (1972). A Binding Protein for Fatty Acids in Cytosol of Intestinal Mucosa, Liver, Myocardium, and Other Tissues. Science. https://doi.org/10.1126/science.177.4043.56
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
