Cited by 712Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Metabolic functions of FABPs—mechanisms and therapeutic implications

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Hotamisligil, Gökhan S., Bernlohr, David A.·2015·Nature Reviews Endocrinology

Abstract

Intracellular and extracellular interactions with proteins enables the functional and mechanistic diversity of lipids. Fatty acid-binding proteins (FABPs) were originally described as intracellular proteins that can affect lipid fluxes, metabolism and signalling within cells. As the functions of this protein family have been further elucidated, it has become evident that they are critical mediators of metabolism and inflammatory processes, both locally and systemically, and therefore are potential therapeutic targets for immunometabolic diseases. In particular, genetic deficiency and small molecule-mediated inhibition of FABP4 (also known as aP2) and FABP5 can potently improve glucose homeostasis and reduce atherosclerosis in mouse models. Further research has shown that in addition to their intracellular roles, some FABPs are found outside the cells, and FABP4 undergoes regulated, vesicular secretion. The circulating form of FABP4 has crucial hormonal functions in systemic metabolism. In this Review we discuss the roles and regulation of both intracellular and extracellular FABP actions, highlighting new insights that might direct drug discovery efforts and opportunities for management of chronic metabolic diseases.

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  1. [175]NCBI Fabp4 [Mus musculus] GenBank: CAJ18597.1 [online], http://www.ncbi.nlm.nih.gov/protein/71060107 2005

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Authors
Hotamisligil, G. S., & Bernlohr, D. A.
Affiliations
University of Minnesota (US)
Corresponding author
Bernlohr, David A.
Venue
Nature Reviews Endocrinology
Published
2015-08-11
Volume
11
Issue
10
Pages
592-605
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
OpenAlex
W1872721533
Cited by
712
References
179
Citations by year
2026: 71 · 2025: 104 · 2024: 88 · 2023: 73 · 2022: 74 · 2021: 77 · 2020: 56 · 2019: 56 · 2018: 41 · 2017: 49 · 2016: 21 · 2015: 2
FWCI
3.68
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Union Chimique Belge
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK064360, DK053189, R01DK064360, R56DK064360, R56DK053189, R01DK053189)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
fatty acid binding protein, FABP4, FABP5, AP-2, fatty acid metabolism, obesity, adipose tissue, glucose homeostasis, atherosclerosis, vesicular secretion, therapeutic target, lipid signaling, inflammation
MeSH terms
Animals, Humans, Inflammation, Gene Expression, Lipid Metabolism, Fatty Acid-Binding Proteins, Mice

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