Relation between REM sleep and intracranial self-stimulation
Abstract
Depriving rats of rapid eye movement (REM) sleep was shown to lower their thresholds and raise their response rates for rewarding brain stimulation. Conversely, allowing rats to self-stimulate while they were being deprived of this sleep form reduced the amount of REM rebound during recovery from deprivation. These results demonstrate a reciprocal relation between rewarding brain stimulation and REM sleep.
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Acute sleep deprivation or chronic partial sleep restriction in animals often leads to enhanced risk taking and reward seeking, including cocaine and alcohol intake, sucrose self-administration, and intracranial self-stimulation.
“Acute sleep deprivation or chronic partial sleep restrictions in animals often leads to enhanced risk taking and reward seeking, including cocaine and alcohol intake, sucrose self-administration, as well as intra-cranial self-stimulations (99–103).”
From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [103]
Animal studies have recapitulated the phenomenon of sleep loss-enhanced reward seeking observed in humans.
“animal studies have recapitulated the phenomenon of sleep loss-enhanced reward seeking observed in humans.”
From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [103]
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Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents
Logan, R. W., Hasler, B. P., Forbes, E. E., Franzen, P. L., Torregrossa, M. M., Huang, Y. H., Buysse, D. J., Clark, D. B., & McClung, C. A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.035 · Cited by 194 · see citing works
Prefrontal cortex to accumbens projections in sleep regulation of reward
Liu, Z., Wang, Y., Cai, L., Li, Y., Chen, B., Dong, Y., & Huang, Y. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0347-16.2016 · Cited by 66 · see citing works
- Authors
- Steiner, S. S., & Ellman, S. J.
- Affiliations
- City College of New York (US)
- Venue
- Science
- Published
- 1972-09-22
- Volume
- 177
- Issue
- 4054
- Pages
- 1122-1124
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980004693
- Cited by
- 77
- References
- 19
- Citations by year
- 2023: 1 · 2022: 2 · 2019: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- REM sleep, intracranial self-stimulation, sleep deprivation, reward, brain stimulation, REM rebound, rats
- MeSH terms
- Animals, Cerebral Cortex, Electrodes, Implanted, Hippocampus, Male, Self Stimulation, Sleep Deprivation, Sleep, REM, Stereotaxic Techniques, Rats
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