Copulation in castrated male rats following combined treatment with estradiol and dihydrotestosterone
Abstract
Castrated male rats injected daily with 2 micrograms of estradiol benzoate (EB) combined with 200 micrograms of dihydrotestosterone propionate (DHTP) displayed masculine mating behavior which was indistinguishable from that of other castrates treated with 200 micrograms of testosterone propionate (TP). Significantly less copulation was seen in rats treated with either 4 micrograms of TP plus 200 micrograms of DHTP or 2 micrograms of EB. Mating in male rats may depend on the action of both estrogenic and 5alpha-dihydro metabolites of testosterone.
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Hormonal action on the bed nucleus of the stria terminalis/medial amygdala vasopressin cell population may help drive aspects of steroid-sensitive sexual behavior since gonadal hormones affect both male sexual behavior and vasopressin expression within the extended amygdala.
“Hormonal action on this cell population may help drive aspects of steroid-sensitive sexual behavior since gonadal hormones affect both male sexual behavior (120, 121) and AVP expression within the extended amygdala (33).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [120]
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- Authors
- Baum, M. J., & Vreeburg, J. T. M.
- Affiliations
- Erasmus University Rotterdam (NL)
- ORCID
- Baum, Michael J.
- Venue
- Science
- Published
- 1973-10-19
- Volume
- 182
- Issue
- 4109
- Pages
- 283-285
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2062438687
- Cited by
- 289
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 9 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 4 · 2012: 5
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- copulation, castration, estradiol benzoate, dihydrotestosterone propionate, testosterone propionate, male mating behavior, estrogen, dihydrotestosterone, androgen-estrogen interaction, male rats
- MeSH terms
- Animals, Castration, Copulation, Drug Combinations, Ejaculation, Estradiol, Injections, Subcutaneous, Male, Sexual Behavior, Animal, Dihydrotestosterone, Rats
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