Effects of androgens and estrogens on the vasopressin and oxytocin innervation of the adult rat brain
Abstract
Recently we reported that castration of rats eliminates vasopressin immunoreactivity in the lateral septum and other areas that appear to receive vasopressin innervation from the bed nucleus of the stria terminalis. Testosterone treatment counteracts this effect of castration. In the present study, we investigated whether this action of testosterone depends on its androgenic or estrogenic metabolites by treating long-term castrated rats with estradiol (E) and/or 5 alpha-dihydrotestosterone (DHT) or testosterone. The brains were then processed for immunocytochemistry or radioimmunoassay. DHT did not increase vasopressin staining in the lateral septum, although it fully restored the size of the seminal vesicles. E did restore the original fiber density, but individual fibers stained more weakly than in sham-operated males. Only treatment with both E and DHT fully restored the vasopressin innervation. This pattern was also reflected in the radioimmunoassay data. The vasopressin content of the lateral septum decreased about 90% after castration but was fully restored by either testosterone or E + DHT treatment. E alone, however, was only half as effective as E + DHT. The treatments had no effect on the oxytocin content of the septum, or on the vasopressin or oxytocin content of the dorsal vagal complex. The results suggest that E mediates most of the effects of testosterone on the vasopressin innervation of the lateral septum. DHT enhances the response to E but has little effect on its own.
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DHT by itself does not restore AVP immunostaining in castrated male rats.
“while Sa-dihydrotestosterone (DHT)which is an androgenic, nonaromatizable metabolite of testosterone generated by reduction (Lieberburg and McEwen, 1975)does not by itself restore AVP immunostaining.”
From Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats (1994) · cites this paper as De Vries et al., 1986
DHT given in combination with E enhances AVP immunostaining in castrated male rats.
“However, if DHT is given in combination with E, it enhances AVP immunostaining (De Vries et al., 1986).”
From Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats (1994) · cites this paper as De Vries et al., 1986
Estradiol partially restores AVP immunostaining in castrated male rats.
“Estradiol (E)-which is an estrogenic metabolite of testosterone generated by aromatization (Naftolin et al., 1975)-partially restores AVP immunostaining in castrated male rats”
From Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats (1994) · cites this paper as De Vries et al., 1986
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“…plasma levels of 50-90 ne/ml E. which comnletelv suuuressed LH release in males, while the dim&sions used for DHT (3 cm, 1.5 mm and 2.4 mm o.d.) previously yielded plasma levels of 0.9-l .8 rig/ml DHT, which fully restored the size of the seminal vesicles in castrated rats (De Vries et al., 1986).”
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- Authors
- De Vries, G. J., Duetz, W., Buijs, R. M., van Heerikhuize, J., & Vreeburg, J. T. M.
- Affiliations
- Erasmus University Rotterdam (NL)
- ORCID
- Buijs, Ruud M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1986-12
- Volume
- 399
- Issue
- 2
- Pages
- 296-302
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2041680408
- Cited by
- 153
- References
- 64
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- vasopressin, oxytocin, androgens, estrogen, testosterone, estradiol, dihydrotestosterone, castration, lateral septum, bed nucleus of the stria terminalis, dorsal vagal complex, seminal vesicle, sex hormones
- MeSH terms
- Animals, Brain, Castration, Estradiol, Male, Oxytocin, Rats, Inbred Strains, Seminal Vesicles, Septum Pellucidum, Dihydrotestosterone, Testosterone, Vasopressins, Rats
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