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Cited by 137Neuroscience and Neuropharmacology ResearchNeurobiology and Insect Physiology ResearchMemory and Neural Mechanisms

Habituation: Regulation through Presynaptic Inhibition

Krasne, Franklin B., Bryan, Joan S.·1973·Science
DOI 10.1126/science.182.4112.590
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Abstract

During tail-flip escape responses of crayfish, synaptic transmission at the habituation-prone synapses of the lateral giant reflex pathway is presynaptically inhibited. This prevents transmitter release and all subsequent postsynaptic actions and spares the reflex from becoming habituated to stimuli produced by an animal's own escape movements. These observations demonstrate the existence of a control circuit whose adaptive function is to regulate the malleability of inherently plastic synapses. They also suggest that regulation of plasticity could be a common use of presynaptic inhibition.

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Crossref · 10.1126/science.182.4112.590

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20 of 20 references verified0 citation errors · 0 not checkable

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  • CD mechanisms allow crayfish to move freely without inadvertently triggering or habituating their reflexive escape responses.

    “CD mechanisms allow crayfish to move freely without inadvertently triggering or habituating their reflexive escape responses15.”

    From Corollary discharge across the animal kingdom (2008) · cites this paper as [15]

  • The crayfish circuitry contains CDIs that receive signals from the lateral giant command neurons, which initiate the escape response.

    “The circuitry contains CDIs that receive signals from the lateral giant command neurons, which initiate the escape response (FIG. 4a).”

    From Corollary discharge across the animal kingdom (2008) · cites this paper as [15]

  • The crayfish CDIs synapse on interneurons that presynaptically inhibit primary afferents from the tail hair cells.

    “The CDIs synapse on to interneurons (called primary afferent depolarizing interneurons) that presynaptically inhibit primary afferents from the tail hair cells.”

    From Corollary discharge across the animal kingdom (2008) · cites this paper as [15]

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Related

Authors
Krasne, F. B., & Bryan, J. S.
Affiliations
University of California, Los Angeles (US)
ORCID
Krasne, Franklin B.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1973-11-09
Volume
182
Issue
4112
Pages
590-592
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.182.4112.590
OpenAlex
W2047789135
Cited by
137
References
20
Citations by year
2026: 1 · 2024: 1 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
2.51
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
habituation, presynaptic inhibition, crayfish, synaptic plasticity, neurotransmitter release, self-generated movement
MeSH terms
Action Potentials, Animals, Astacoidea, Evoked Potentials, Feedback, Habituation, Psychophysiologic, Motor Neurons, Neural Pathways, Sensory Receptor Cells, Reflex, Startle, Synapses, Tail

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