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Enhancement of Growth of Virulent Strains of Escherichia coli by Interleukin-1
Abstract
Interleukin-1 (IL-1) is a polypeptide cytokine that mediates many physiological responses to infection and inflammation and is a growth factor for certain mammalian cells. Virulent and avirulent clinical isolates of Escherichia coli were grown in culture media in the presence of human IL-1. IL-1β, but not tumor necrosis factor or IL-4, enhanced the growth of virulent, but not avirulent, E. coli . This enhancement was blocked by the IL-1 receptor antagonist (IL-1ra). Radiolabeled IL-1 bound to virulent but not avirulent E. coli in a specific and saturable fashion; IL-1ra inhibited this binding. Thus, human IL-1 may recognize a functional IL-1-like receptor structure on virulent E. coli and may be a virulence factor for bacterial pathogenicity.
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Carter, D. B., Deibel, M. R., Dunn, C. J., Tomich, C.-S. C., Laborde, A. L., Slightom, J. L., Berger, A. E., Bienkowski, M. J., Sun, F. F., McEwan, R. N., et al. (1990) · Nature · doi:10.1038/344633a0 · Cited by 601
Cited by
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Dickson, R. P., Erb-Downward, J. R., Martinez, F. J., & Huffnagle, G. B. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105238 · Cited by 953
Haziot, A., Ferrero, E., Köntgen, F., Hijiya, N., Yamamoto, S., Silver, J., Stewart, C. L., & Goyert, S. M. (1996) · Immunity · doi:10.1016/s1074-7613(00)80254-x · Cited by 743
The respiratory tract microbiome and lung inflammation: a two-way street.
Huffnagle, G. B., Dickson, R. P., & Lukacs, N. W. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.108 · Cited by 535
The role of the microbiome in exacerbations of chronic lung diseases
Dickson, R. P., Martinez, F. J., & Huffnagle, G. B. (2014) · The Lancet · doi:10.1016/s0140-6736(14)61136-3 · Cited by 495
Henderson, B., Poole, S., & Wilson, M. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.2.316-341.1996 · Cited by 419
Metadata
- Authors
- Porat, R., Clark, B. D., Wolff, S. M., & Dinarello, C. A.
- Venue
- Science
- Published
- 1991-10-18
- Volume
- 254
- Issue
- 5030
- Pages
- 430-432
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967309573
- Cited by
- 190
- References
- 1
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Porat, R., Clark, B. D., Wolff, S. M., & Dinarello, C. A. (1991). Enhancement of Growth of Virulent Strains of Escherichia coli by Interleukin-1. Science. https://doi.org/10.1126/science.1833820
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
