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A Distinct Potassium Channel Polypeptide Encoded by the Drosophila eag Locus
Abstract
Many of the signaling properties of neurons and other electrically excitable cells are determined by a diverse family of potassium channels. A number of genes that encode potassium channel polypeptides have been cloned from various organisms on the basis of their sequence similarity to the Drosophila Shaker ( Sh ) locus. As an alternative strategy, a molecular analysis of other Drosophila genes that were defined by mutations that perturb potassium channel function was undertaken. Sequence analysis of complementary DNA from the ether à go-go ( eag ) locus revealed that it encodes a structural component of potassium channels that is related to but is distinct from all identified potassium channel polypeptides.
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Cited by
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Pardo, L. A., del Camino, D., Sánchez, A., Alves, F., Brüggemann, A., Beckh, S., & Stühmer, W. (1999) · The EMBO Journal · doi:10.1093/emboj/18.20.5540 · Cited by 446
Pongs, O., Lindemeier, J., Zhu, X. R., Theil, T., Engelkamp, D., Krah-Jentgens, I., Lambrecht, H., Koch, K. W., Schwemer, J., Rivosecchi, R., et al. (1993) · Neuron · doi:10.1016/0896-6273(93)90267-u · Cited by 357
Mammalian Per-Arnt-Sim Proteins in Environmental Adaptation
McIntosh, B. E., Hogenesch, J. B., & Bradfield, C. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135922 · Cited by 352
Schönherr, R., & Heinemann, S. H. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021410 · Cited by 320
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Metadata
- Authors
- Warmke, J., Drysdale, R., & Ganetzky, B.
- Venue
- Science
- Published
- 1991-06-14
- Volume
- 252
- Issue
- 5012
- Pages
- 1560-1562
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050357864
- Cited by
- 355
- References
- 0
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Warmke, J., Drysdale, R., & Ganetzky, B. (1991). A Distinct Potassium Channel Polypeptide Encoded by the Drosophila eag Locus. Science. https://doi.org/10.1126/science.1840699
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