The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage
Abstract
The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.
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Citations
Cites
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765
Self-citationA regulatory hierarchy for cell specialization in yeast
Herskowitz, I. (1989) · Nature · doi:10.1038/342749a0 · Cited by 590
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Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
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Metadata
- Authors
- Weintraub, H., Davis, R., Tapscott, S., Thayer, M., Krause, M., Benezra, R., Blackwell, T. K., Turner, D., Rupp, R., Hollenberg, S., Zhuang, Y., & Lassar, A.
- Venue
- Science
- Published
- 1991-02-15
- Volume
- 251
- Issue
- 4995
- Pages
- 761-766
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2103735500
- Cited by
- 1,572
- References
- 2
- FWCI
- 57.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weintraub, H., Davis, R., Tapscott, S., Thayer, M., Krause, M., Benezra, R., Blackwell, T. K., Turner, D., Rupp, R., Hollenberg, S., Zhuang, Y., & Lassar, A. (1991). The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage. Science. https://doi.org/10.1126/science.1846704
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