The DOI matches its Crossref record.
Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor
Open accessAbstract
Interleukin-8 (IL-8) is an inflammatory cytokine that activates neutrophil chemotaxis, degranulation, and the respiratory burst. Neutrophils express receptors for IL-8 that are coupled to guanine nucleotide-binding proteins (G proteins); binding of IL-8 to its receptor induces the mobilization of intracellular calcium stores. A cDNA clone from HL-60 neutrophils, designated p2, has now been isolated that encodes a human IL-8 receptor. When p2 is expressed in oocytes from Xenopus laevis , the oocytes bind 125 I-labeled IL-8 specifically and respond to IL-8 by mobilizing calcium stores with an EC 50 of 20 nM. This IL-8 receptor has 77% amino acid identity with a second human neutrophil receptor isotype that binds IL-8 with higher affinity. It also exhibits 69% amino acid identity with a protein reported to be an N-formyl peptide receptor from rabbit neutrophils, but less than 30% identity with all other known G protein-coupled receptors, including the human N-formyl peptide receptor.
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Cited by
The Interleukin-8 Pathway in Cancer
Waugh, D. J. J., & Wilson, C. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4843 · Cited by 2,103
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817
Self-citationCole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., et al. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.2009 · Cited by 870
Interleukin-8 and the chemokine family
Baggiolini, M., Loetscher, P., & Moser, B. (1995) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(94)00088-6 · Cited by 400
CXCR2 antagonists for the treatment of pulmonary disease
Chapman, R. W., Phillips, J. E., Hipkin, R. W., Curran, A. K., Lundell, D., & Fine, J. S. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.10.005 · Cited by 214
Iwamoto, S., Omi, T., Kajii, E., & Ikemoto, S. (1995) · Blood · doi:10.1182/blood.v85.3.622.bloodjournal853622 · Cited by 126
Gessler, P., Pfenninger, J., Pfammatter, J.-P., Carrel, T., & Dahinden, C. (2002) · Intensive Care Medicine · doi:10.1007/s00134-002-1525-x · Cited by 24
Metadata
- Authors
- Murphy, P. M., & Tiffany, H. L.
- Venue
- Science
- Published
- 1991-09-13
- Volume
- 253
- Issue
- 5025
- Pages
- 1280-1283
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058902088
- Cited by
- 871
- References
- 0
- FWCI
- 22.90
- Type
- journal article
- Language
- en
- Open access
- green
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