CXCR2 antagonists for the treatment of pulmonary disease

Chapman, R.W.; Phillips, J.E.; Hipkin, R.W.; Curran, A.K.; Lundell, D.; Fine, J.S.

doi:10.1016/j.pharmthera.2008.10.005

Cited by 214Chemokine receptors and signalingChronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseases

CXCR2 antagonists for the treatment of pulmonary disease

Chapman, R.W., Phillips, J.E., Hipkin, R.W., Curran, A.K., Lundell, D., Fine, J.S.·2009·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2008.10.005

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Abstract

Chemokines have long been implicated in the initiation and amplification of inflammatory responses by virtue of their role in leukocyte chemotaxis. The expression of one of the receptors for these chemokines, CXCR2, on a variety of cell types and tissues suggests that these receptors may have a broad functional role under both constitutive conditions and in the pathophysiology of a number of acute and chronic diseases. With the development of several pharmacological, immunological and genetic tools to study CXCR2 function, an important role for this CXC chemokine receptor subtype has been identified in chronic obstructive pulmonary disease (COPD), asthma and fibrotic pulmonary disorders. Interference with CXCR2 receptor function has demonstrated different effects in the lungs including inhibition of pulmonary damage induced by neutrophils (PMNs), antigen or irritant-induced goblet cell hyperplasia and angiogenesis/collagen deposition caused by lung injury. Many of these features are common to inflammatory and fibrotic disorders of the lung. Clinical trials evaluating small molecule CXCR2 antagonists in COPD, asthma and cystic fibrosis are currently underway. These studies hold considerable promise for identifying novel and efficacious treatments of pulmonary disorders.

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CXCR2 receptor antagonists are in clinical trials for chronic inflammatory diseases.
“CXCR2 receptor antagonists are in clinical trials for chronic inflammatory diseases (Chapman et al., 2009)”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Chapman et al., 2009

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Authors: Chapman, R. W., Phillips, J. E., Hipkin, R. W., Curran, A. K., Lundell, D., & Fine, J. S.
Corresponding author: Chapman, R.W.
ORCID: Chapman, R.W.
Phillips, J.E.
Curran, A.K.
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2009-01
Volume: 121
Issue: 1
Pages: 55-68
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2008.10.005
OpenAlex: W1988019968
Cited by: 214
References: 205
Citations by year: 2026: 1 · 2025: 8 · 2024: 3 · 2023: 12 · 2022: 2 · 2021: 10 · 2020: 12 · 2019: 3 · 2018: 15 · 2017: 11 · 2016: 10 · 2015: 21 · 2014: 23 · 2013: 17 · 2012: 23
FWCI: 1.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Keywords: CXCR2 antagonist, chemokines, chronic obstructive pulmonary disease, asthma, pulmonary fibrosis, cystic fibrosis, neutrophil recruitment, goblet cell hyperplasia, lung injury, angiogenesis, collagen deposition, small molecule antagonists, clinical trials
MeSH terms: Animals, Chemotaxis, Leukocyte, Humans, Lung Diseases, Chemokines, CXC, Receptors, Interleukin-8B, Drug Discovery

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CXCR2 antagonists for the treatment of pulmonary disease

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