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Peripheral Selection of the T Cell Repertoire
Abstract
T lymphocytes undergo selection events not only in the thymus, but also after they leave the thymus and reside in the periphery. Peripheral selection was found to be dependent on T cell receptor (TCR)-ligand interactions but to differ from thymic selection with regard to specificity and mechanism. Unlike thymic selection, peripheral selection required binding of antigen to the TCR, and it induced expansion of T cell clones. Tolerance to self antigens that are restricted to the periphery occurred through the elimination of self-reactive T cells and by the clonal anergy, which was associated with down-regulation of the αβ TCR and CD8.
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Citations
Cited by
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,820
Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979
Steinman, R. M., Hawiger, D., & Nussenzweig, M. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141040 · Cited by 3,122
Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity · doi:10.1016/s1074-7613(00)80089-8 · Cited by 2,749
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775
Metadata
- Authors
- Rocha, B., & von Boehmer, H.
- Venue
- Science
- Published
- 1991-03-08
- Volume
- 251
- Issue
- 4998
- Pages
- 1225-1228
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986356667
- Cited by
- 647
- References
- 0
- FWCI
- 20.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rocha, B., & von Boehmer, H. (1991). Peripheral Selection of the T Cell Repertoire. Science. https://doi.org/10.1126/science.1900951
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