The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Stereospecific Effects of Inhalational General Anesthetic Optical Isomers on Nerve Ion Channels
Abstract
Although it is generally agreed that general anesthetics ultimately act on neuronal ion channels, there is considerable controversy over whether this occurs by direct binding to protein or secondarily by nonspecific perturbation of lipids. Very pure optical isomers of the inhalational general anesthetic isoflurane exhibited clear stereoselectivity in their effects on particularly sensitive ion channels in identified molluscan central nervous system neurons. At the human median effect dose (ED 50 ) for general anesthesia, the (+)-isomer was about twofold more effective than the (-)-isomer both in eliciting the anesthetic-activated potassium current I K (An) and in inhibiting a current mediated by neuronal nicotinic acetylcholine receptors. For inhibiting the much less sensitive transient potassium current I A , the (-)-isomer was marginally more potent than the (+)-isomer. Both isomers were equally effective at disrupting lipid bilayers.
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Citations
Cites
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Self-citationPharmacology of Ketamine Isomers in Surgical Patients
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Self-citationWhat is the molecular nature of general anaesthetic target sites?
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Genetic Regulation of Fruit Development and Ripening
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Metadata
- Authors
- Franks, N. P., & Lieb, W. R.
- Venue
- Science
- Published
- 1991-10-18
- Volume
- 254
- Issue
- 5030
- Pages
- 427-430
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021818277
- Cited by
- 280
- References
- 15
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- closed
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