Volatile general anaesthetics activate a novel neuronal K+ current

Franks, N. P.; Lieb, W. R.

doi:10.1038/333662a0

Cited by 199Ion channel regulation and functionAnesthesia and Sedative AgentsNeuroscience and Neuropharmacology Research

Volatile general anaesthetics activate a novel neuronal K+ current

Franks, N. P., Lieb, W. R.·1988·Nature

DOI 10.1038/333662a0

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Abstract

Although it is still controversial whether the primary target sites underlying general anaesthesia are proteins or lipids, it is generally thought that the ultimate targets are ion channels in nerve membranes. One approach to finding these targets is to study the effects of general anaesthetics on identified neurons, where differential effects on neuronal activity can be pursued to the molecular level. Here we report that amongst a group of apparently identical molluscan neurons having endogenous firing activity, a single cell displays an unusual sensitivity to volatile agents (which, at surgical levels, completely inhibit its activity). We further show that this sensitivity is due to a novel anaesthetic-activated K+ current, which is found in the sensitive cell but not in the surrounding insensitive cells. This K+ conductance is not appreciably voltage-gated and persists for as long as the anaesthetic is present. The response to anaesthetics is completely reversible and saturates at low anaesthetic partial pressures: the half-maximal response for halothane occurs at 0.0063 atm, close to its minimum alveolar concentration (0.0075 atm) in man.

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Volatile anesthetics can potentiate hyperpolarizing potassium currents in Lymnaea stagnalis.
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From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [47]

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Authors: Franks, N. P., & Lieb, W. R.
Affiliations: Imperial College London (GB)
ORCID: Franks, N. P.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1988-06
Volume: 333
Issue: 6174
Pages: 662-664
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/333662a0
OpenAlex: W2002422188
Cited by: 199
References: 20
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2021: 7 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 6
FWCI: 3.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: volatile anesthetics, general anesthesia, potassium currents, ion channels, halothane, molluscan neurons, minimum alveolar concentration
MeSH terms: Animals, Dose-Response Relationship, Drug, Halothane, Ion Channels, Kinetics, Lymnaea, Membrane Potentials, Neurons, Potassium, In Vitro Techniques

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Volatile general anaesthetics activate a novel neuronal K+ current

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