The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expression and Activity of the POU Transcription Factor SCIP
Abstract
POU proteins have been shown to transcriptionally activate cell-specific genes and to participate in the determination of cell fate. It is therefore thought that these proteins function in development through the stable activation of genes that define specific developmental pathways. Evidence is provided here for an alternative mode of action. The primary structure of SCIP, a POU protein expressed by developing Schwann cells of the peripheral nervous system, was deduced and SCIP activity was studied. Both in normal development and in response to nerve transection, SCIP expression was transiently activated only during the period of rapid cell division that separates the premyelinating and myelinating phases of Schwann cell differentiation. In cotransfection assays, SCIP acted as a transcriptional repressor of myelin-specific genes.
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Cites
Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070
Cited by
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Sox10, a Novel Transcriptional Modulator in Glial Cells
Kuhlbrodt, K., Herbarth, B., Sock, E., Hermans-Borgmeyer, I., & Wegner, M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00237.1998 · Cited by 781
Nerve Injury, Axonal Degeneration and Neural Regeneration: Basic Insights
Stoll, G., & Müller, H. W. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00229.x · Cited by 599
POU-domain transcription factors: pou-er-ful developmental regulators.
Rosenfeld, M. G. (1991) · Genes & Development · doi:10.1101/gad.5.6.897 · Cited by 447
Strubin, M., Newell, J. W., & Matthias, P. (1995) · Cell · doi:10.1016/0092-8674(95)90500-6 · Cited by 374
Metadata
- Authors
- Monuki, E. S., Kuhn, R., Weinmaster, G., Trapp, B. D., & Lemke, G.
- Venue
- Science
- Published
- 1990-09-14
- Volume
- 249
- Issue
- 4974
- Pages
- 1300-1303
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006591452
- Cited by
- 239
- References
- 1
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Monuki, E. S., Kuhn, R., Weinmaster, G., Trapp, B. D., & Lemke, G. (1990). Expression and Activity of the POU Transcription Factor SCIP. Science. https://doi.org/10.1126/science.1975954
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
