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Cited by 44Clinical Nutrition and GastroenterologyThyroid Disorders and TreatmentsSepsis Diagnosis and Treatment

Altered thyroid hormone levels in bacterial sepsis: The role of nutritional adequacy

Richmand, David A., Molitch, Mark E., O'Donnell, Thomas F.·1980·Metabolism
DOI 10.1016/0026-0495(80)90036-0
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Abstract

Depressed triiodothyronine and elevated reverse triiodothyronine levels are commonly seen in patients with acute and chronic illness and in patients receiving markedly hypocaloric diets. To investigate the role of nutritional adequacy in causing the altered thyroid hormone levels found in severe illness, we studied patients with bacterial sepsis who were receiving a variety of nutritional regimens. Thirteen patients received only 5% dextrose in water (600-1000 kcal/day), 7 of whom were in shock. Seven patients received total parenteral nutrition (2500-3500 kcal/day). Analysis of thyroid hormone levels in these groups and in controls shows that a large component of the alteration in thyroid hormone levels found in patients with severe illness is due to the caloric deprivation associated with such severe illness.

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  • Diminished food intake plays an additional role as NTIS is associated with diminished appetite and nutritional intake.

    “Diminished food intake plays an additional role as NTIS is associated with diminished appetite and nutritional intake [71–74].”

    From An update on non-thyroidal illness syndrome (2021) · cites this paper as [72]

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Authors
Richmand, D. A., Molitch, M. E., & O'Donnell, T. F.
Affiliations
Tufts University (US)
Corresponding author
Molitch, Mark E.
ORCID
Molitch, Mark E.
Venue
Metabolism
Publisher
Elsevier BV
Published
1980-10
Volume
29
Issue
10
Pages
936-942
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(80)90036-0
OpenAlex
W2048347345
Cited by
44
References
53
Citations by year
2025: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2013: 1
FWCI
0.91
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
Tufts University School of Medicine
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Keywords
bacterial sepsis, thyroid hormones, triiodothyronine, reverse T3, nutritional adequacy, caloric deprivation, hypocaloric diet, total parenteral nutrition, septic shock, severe illness, hypothyroidism
MeSH terms
Acute Disease, Adult, Aged, Bacteria, Chronic Disease, Female, Humans, Male, Middle Aged, Nutritional Physiological Phenomena, Thyrotropin, Thyroxine, Triiodothyronine, Triiodothyronine, Reverse, Sepsis

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