The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR
Abstract
Human immunodeficiency virus type 1 (HIV-1) gene expression is activated by Tat, a virally encoded protein. Tat trans-activation requires viral (trans-activation—responsive; TAR) RNA sequences located in the R region of the long terminal repeat (LTR). Existing evidence suggests that Tat probably cooperates with cellular factors that bind to TAR RNA in the overall trans-activation process. A HeLa complementary DNA was isolated and characterized that encodes a TAR RNA-binding protein (TRBP). TRBP activated the HIV-1 LTR and was synergistic with Tat function.
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Citations
Cites
Tat trans-activates the human immunodeficiency virus through a nascent RNA target
Berkhout, B., Silverman, R. H., & Jeang, K.-T. (1989) · Cell · doi:10.1016/0092-8674(89)90289-4 · Cited by 647
Self-citationMalim, M. H., Tiley, L. S., McCarn, D. F., Rusche, J. R., Hauber, J., & Cullen, B. R. (1990) · Cell · doi:10.1016/0092-8674(90)90670-a · Cited by 430
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Metadata
- Authors
- Gatignol, A., Buckler-White, A., Berkhout, B., & Jeang, K.-T.
- Venue
- Science
- Published
- 1991-03-29
- Volume
- 251
- Issue
- 5001
- Pages
- 1597-1600
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076941373
- Cited by
- 389
- References
- 2
- FWCI
- 6.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR. https://app.cochat.ai/papers/10.1126/science.2011739
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- Gatignol, A., Buckler-White, A., Berkhout, B., & Jeang, K.-T. (1991). Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR. Science. https://doi.org/10.1126/science.2011739
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