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Spiral Calcium Wave Propagation and Annihilation in Xenopus laevis Oocytes
Abstract
Intracellular calcium (Ca 2+ ) is a ubiquitous second messenger. Information is encoded in the magnitude, frequency, and spatial organization of changes in the concentration of cytosolic free Ca 2+ . Regenerative spiral waves of release of free Ca 2+ were observed by confocal microscopy in Xenopus laevis oocytes expressing muscarinic acetylcholine receptor subtypes. This pattern of Ca 2+ activity is characteristic of an intracellular milieu that behaves as a regenerative excitable medium. The minimal critical radius for propagation of focal Ca 2+ waves (10.4 micrometers) and the effective diffusion constant for the excitation signal (2.3 × 10 -6 square centimeters per second) were estimated from measurements of velocity and curvature of circular wavefronts expanding from foci. By modeling Ca 2+ release with cellular automata, the absolute refractory period for Ca 2+ stores (4.7 seconds) was determined. Other phenomena expected of an excitable medium, such as wave propagation of undiminished amplitude and annihilation of colliding wavefronts, were observed.
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Cited by
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Stationary and drifting spiral waves of excitation in isolated cardiac muscle
Davidenko, J. M., Pertsov, A. V., Salomonsz, R., Baxter, W., & Jalife, J. (1992) · Nature · doi:10.1038/355349a0 · Cited by 1,256
Inositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias
KLÉBER, A. G., & RUDY, Y. (2004) · Physiological Reviews · doi:10.1152/physrev.00025.2003 · Cited by 1,083
New mammalian chloride channel identified by expression cloning
Paulmichl, M., Li, Y., Wickman, K., Ackerman, M., Peralta, E., & Clapham, D. (1992) · Nature · doi:10.1038/356238a0 · Cited by 323
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Metadata
- Authors
- Lechleiter, J., Girard, S., Peralta, E., & Clapham, D.
- Venue
- Science
- Published
- 1991-04-05
- Volume
- 252
- Issue
- 5002
- Pages
- 123-126
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977356579
- Cited by
- 730
- References
- 0
- FWCI
- 68.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lechleiter, J., Girard, S., Peralta, E., & Clapham, D. (1991). Spiral Calcium Wave Propagation and Annihilation in Xenopus laevis Oocytes. Science. https://doi.org/10.1126/science.2011747
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