The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A corticosteroid Receptor in Neuronal Membranes
Abstract
Steroids may rapidly alter neuronal function and behavior through poorly characterized, direct actions on neuronal membranes. The membrane-bound receptors mediating these behavioral responses have not been identified. [3H]Corticosterone labels a population of specific, high-affinity recognition sites (dissociation constant = 0.51 nanomolar) in synaptic membranes from an amphibian brain. These binding sites were localized by receptor autoradiography in the neuropil, outside the regions of perikarya. The affinities of corticoids for this [3H]corticosterone binding site were linearly related to their potencies in rapidly suppressing male reproductive behavior. Thus, it appears that brain membranes contain a corticosteroid receptor that could participate in the regulation of behavior.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“the discovery of adrenal steroid receptors that are G protein coupled in the amphibian brain (Orchinik et al., 1991)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Orchinik et al., 1991
Citations
Cites
Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., & Paul, S. M. (1986) · Science · doi:10.1126/science.2422758 · Cited by 2,225
STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS
Yamamoto, K. R. (1985) · Annual Review of Genetics · doi:10.1146/annurev.ge.19.120185.001233 · Cited by 1,850
Adrenal steroid receptors and actions in the nervous system
McEwen, B. S., de Kloet, E. R., & Rostène, W. H. (1986) · Physiological Reviews · doi:10.1152/physrev.1986.66.4.1121 · Cited by 1,238
Steroid Receptor Family: Structure and Functions
Carson, M. A., Schrader, W. T., & O’Malley, B. W. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-2-201 · Cited by 813
Harrison, N. L., Majewska, M., Harrington, J. W., & Barker, J. L. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-5347(25)00332-5 · Cited by 611
de Kloet, E. R., & Reul, J. M. H. M. (1987) · Psychoneuroendocrinology · doi:10.1016/0306-4530(87)90040-0 · Cited by 595
Weiland, G. A., & Molinoff, P. B. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90324-6 · Cited by 555
Neurosteroids act on recombinant human GABAA receptors
Puia, G., Santi, M., Vicini, S., Pritchett, D. B., Purdy, R. H., Paul, S. M., Seeburg, P. H., & Costa, E. (1990) · Neuron · doi:10.1016/0896-6273(90)90202-q · Cited by 514
The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor
Majewska, M. D., Demirgo¨ren, S., Spivak, C. E., & London, E. D. (1990) · Brain Research · doi:10.1016/0006-8993(90)90261-9 · Cited by 433
Biochemistry, Molecular Biology, and Physiology of the Glucocorticoid Receptor*
Gustafsson, J.-Α., Carlstedt‐Duke, J., Poellinger, L., Okret, S., Wikström, A., Brönnegård, M., Gillner, M., Dong, Y., Fuxé, K., Cintra, A., et al. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-185 · Cited by 402
Flagged first, then by citations
Research works printed but not linked: 5
- LESHCHENKO, M.V., FARMAKOLOGIIA I TOKSIKOLOGIIA 50: 60 (1987).
- MEDHI, A.Z., GENERAL AND COMPARATIVE ENDOCRINOLOGY 53: 475 (1984).
- ORCHINIK, M, SOCIETY FOR NEUROSCIENCE. ABSTRACTS 15: 759 (1989).
- Riker, W. F., Adrenal Actions on Brain: 69 (1982).
- Whittaker, V. P., Handbook of Neurochemistry 2: 327 (1969).
Cited by
Sorted by citations
Items 501–522 of 522
Glucocorticoid Action in the Mediobasal Hypothalamus Regulates Glucose Production In Vivo
Beaulieu-Bayne, E. (2019) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-eahb-a894
Trophic Factor and Nutritional and Hormonal Regulation of Brain Development
Pleasure, J. R., & Pleasure, D. (2004) · Elsevier eBooks · doi:10.1016/b978-0-7216-9654-6.50176-4
Trophic Factor and Nutritional and Hormonal Regulation of Brain Development
Pleasure, J. R., & Pleasure, D. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-3479-7.10168-5
Cellular Localization of Receptors Mediating the Actions of Steroid Hormones
Judy, B. M., & Welshons, W. V. (1997) · Comprehensive physiology · doi:10.1002/j.2040-4603.1997.tb01441.x
How stress, anxiety, and fear affect eating
Carr, J. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29218-7.00006-7
Berry, J. N. (2013) · UKnowledge (University of Kentucky)
Graf, E. N. (2012) · e-Publications@Marquette (Marquette University)
Functions of the Mineralocorticoid Receptor in the Hippocampus.
Rozeboom, A. M. (2008) · Deep Blue (University of Michigan)
Mechanisms of Glucocorticoid Actions in Stress and Brain Aging
Porter, N. M., Herman, J. P., & Landfield, P. W. (2000) · Comprehensive physiology · doi:10.1002/j.2040-4603.2000.tb01519.x
Grimes, T. F., Pope, J., Stenning, J., Smith, T. E., Kent, D. G., Baker, S. C., Brackenbury, W. J., Willems, L. I., & Holding, A. N. (2026) · Biochemical Journal · doi:10.1042/bcj20253216
Violle, N. (2008) · doi:10.70675/0fdfdb4bz7b66z4325z94f5z18b1afd69a36
Toyoda, F., Haraguchi, S., Yamamoto, K., Matsunaga, M., Takase, M., Nakada, T., Nakamura, M., Hasunuma, I., Tsutsui, K., & Kikuyama, S. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115347
Estradiol predicts pausing during mate-choice updating in a stress-buffered treefrog
Baugh, A. T., Bee, M. A., Eyiolowope, J., Hou, J., & Kim, C. (2026) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2026.115019
Evolution and Stress Responses to Changes in Environment
Cabej, N. R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-415831-3.00007-0
Modulation of glucocorticoid activity by metabolism of steroids in non-lymphoid organs
Walker, B. R. (1997) · Springer eBooks · doi:10.1007/978-1-4471-0931-0_4
Lawrence (1998) · doi:10.1002/1529-0131(199805)41:5
Ferguson, G. W., Jones, J. R., Gehrmann, W. H., Hammack, S. H., Talent, L. G., Hudson, R. D., Dierenfeld, E. S., Fitzpatrick, M. P., Frye, F. L., Holick, M. F., et al. (1996) · Zoo Biology · doi:10.1002/(sici)1098-2361(1996)15:3
Metadata
- Authors
- Orchinik, M., Murray, T. F., & Moore, F. L.
- Affiliations
- Oregon State University (US)
- ORCID
- Murray, Thomas F.
- Venue
- Science
- Published
- 1991-06-28
- Volume
- 252
- Issue
- 5014
- Pages
- 1848-1851
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061928804
- Cited by
- 523
- References
- 36
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 12 · 2015: 13 · 2014: 19 · 2013: 20 · 2012: 20
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- corticosteroid receptors, cell surface receptors, corticosterone binding, synaptic membranes, neuronal membrane, amphibian brain, male reproductive behavior, behavioral regulation, steroid binding affinity
- MeSH terms
- Amphibians, Animals, Autoradiography, Binding, Competitive, Brain, Cell Fractionation, Cell Membrane, Corticosterone, Kinetics, Male, Neurons, Receptors, Glucocorticoid, Sexual Behavior, Animal, Synaptosomes, Tritium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
