The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels
Abstract
The function of the heart depends critically on an adequate oxygen supply through the coronary arteries. Coronary arteries dilate when the intravascular oxygen tension decreases. Hypoxic vasodilation in isolated, perfused guinea pig hearts can be prevented by glibenclamide, a blocker of adenosine triphosphate (ATP)-sensitive potassium channels, and can be mimicked by cromakalim, which opens ATP-sensitive potassium channels. Opening of potassium channels in coronary smooth muscle cells and the subsequent drop in intracellular calcium is probably the major cause of hypoxic and ischemic vasodilation in the mammalian heart.
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Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle
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Adenosine 5'-Triphosphate-Sensitive Potassium Channels
Ashcroft, F. M. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.000525 · Cited by 892
The pharmacology of potassium channels and their therapeutic potential
Cook, N. S. (1988) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(88)90238-6 · Cited by 571
Gerlach, E., Deuticke, B., & Dreisbach, R. H. (1963) · Die Naturwissenschaften · doi:10.1007/bf00639287 · Cited by 215
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Nees, S., Herzog, V., Becker, B. F., Böck, M., Rosiers, C. D., & Gerlach, E. (1985) · Basic Research in Cardiology · doi:10.1007/bf01907915 · Cited by 202
Escande, D., Thuringer, D., Leguern, S., & Cavero, I. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90184-2 · Cited by 193
BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle.
Sanguinetti, M. C., Scott, A. L., Zingaro, G. J., & Siegl, P. K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8360 · Cited by 192
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Cited by
Regulation of coronary blood flow during exercise
Duncker, D. J., & Bache, R. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00045.2006 · Cited by 936
Bondjers, C., He, L., Takemoto, M., Norlin, J., Asker, N., Hellström, M., Lindahl, P., Betsholtz, C., Bondjers, C., He, L., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-4944fje · Cited by 193
The regulation of ion channels and transporters by glycolytically derived ATP
Dhar-Chowdhury, P., Malester, B., Rajacic, P., & Coetzee, W. A. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7332-3 · Cited by 107
Coupling of muscle metabolism and muscle blood flow in capillary units during contraction
Murrant, C. L., & Sarelius, I. H. (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00706.x · Cited by 101
Oxygen Sensing in Retinal Health and Disease
Lange, C. A. K., & Bainbridge, J. W. B. (2012) · Ophthalmologica · doi:10.1159/000331418 · Cited by 86
Metadata
- Authors
- Daut, J., Maier-Rudolph, W., von Beckerath, N., Mehrke, G., Günther, K., & Goedel-Meinen, L.
- Venue
- Science
- Published
- 1990-03-16
- Volume
- 247
- Issue
- 4948
- Pages
- 1341-1344
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053912690
- Cited by
- 593
- References
- 13
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels. https://app.cochat.ai/papers/10.1126/science.2107575
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- Daut, J., Maier-Rudolph, W., von Beckerath, N., Mehrke, G., Günther, K., & Goedel-Meinen, L. (1990). Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels. Science. https://doi.org/10.1126/science.2107575
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
