Regulation of coronary blood flow during exercise

Duncker, Dirk J.; Bache, Robert J.

doi:10.1152/physrev.00045.2006

Cited by 936Cardiovascular and exercise physiologyCardiac Imaging and DiagnosticsNitric Oxide and Endothelin Effects

Regulation of coronary blood flow during exercise

Duncker, Dirk J., Bache, Robert J.·2008·Physiological Reviews

DOI 10.1152/physrev.00045.2006

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Abstract

Exercise is the most important physiological stimulus for increased myocardial oxygen demand. The requirement of exercising muscle for increased blood flow necessitates an increase in cardiac output that results in increases in the three main determinants of myocardial oxygen demand: heart rate, myocardial contractility, and ventricular work. The approximately sixfold increase in oxygen demands of the left ventricle during heavy exercise is met principally by augmenting coronary blood flow (~5-fold), as hemoglobin concentration and oxygen extraction (which is already 70-80% at rest) increase only modestly in most species. In contrast, in the right ventricle, oxygen extraction is lower at rest and increases substantially during exercise, similar to skeletal muscle, suggesting fundamental differences in blood flow regulation between these two cardiac chambers. The increase in heart rate also increases the relative time spent in systole, thereby increasing the net extravascular compressive forces acting on the microvasculature within the wall of the left ventricle, in particular in its subendocardial layers. Hence, appropriate adjustment of coronary vascular resistance is critical for the cardiac response to exercise. Coronary resistance vessel tone results from the culmination of myriad vasodilator and vasoconstrictors influences, including neurohormones and endothelial and myocardial factors. Unraveling of the integrative mechanisms controlling coronary vasodilation in respons…

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Moderate-intensity activities done for durations of less than 1 min might not be long enough to induce pronounced changes to the coronary vasculature when compared with longer bouts.
“Moderate-intensity activities done for durations of less than 1 min might not be long enough to induce pronounced changes to the coronary vasculature when compared with longer bouts.28,29”
From Brief bouts of device-measured intermittent lifestyle physical activity and its association with major adverse cardiovascular events and mortality in people who do not exercise: A prospective cohort study (2023) · cites this paper as [28]

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064 · see citing works
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works
Textbook of Work Physiology
Åstrand, P., & Rodahl, K. (1970) · Andalas University Repository (Andalas University) · Cited by 4,451 · see citing works
Cardiovascular System
Stoschitzky, K. (2000) · Handbooks of pharmacology and toxicology · doi:10.1201/9781420036961.ch18 · Cited by 3,258 · see citing works
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., & Humphrey, P. P. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06783-3 · Cited by 2,997 · see citing works
Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension
Panza, J. A., Quyyumi, A. A., Brush, J. E., & Epstein, S. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230105 · Cited by 2,366 · see citing works
Physiological roles and properties of potassium channels in arterial smooth muscle
Nelson, M. T., & Quayle, J. M. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.4.c799 · Cited by 2,161 · see citing works
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
Marc De Gasparo, B., Catt, K. J., Inagami, T., Wright, J. W., & Unger, T. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01458-3 · Cited by 2,131 · see citing works
Angiotensin II receptors and angiotensin II receptor antagonists.
Timmermans, P. B. M. W. M., Wong, P. C., Chiu, A. T., Herblin, W. F., Benfield, P. A., Carini, D. J., Lee, R. J., Wexler, R. R., Saye, J. A., & Smith, R. D. (1993) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00446-6 · Cited by 1,854 · see citing works
The Respiratory System
Sorokin, S. P. (1983) · doi:10.1007/978-1-349-06859-3_23 · Cited by 1,783 · see citing works
Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology.
Rubanyi, G. M., & Polokoff, M. A. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06809-7 · Cited by 1,661 · see citing works
Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle
Standen, N. B., Quayle, J. M., Davies, N. W., Brayden, J. E., Huang, Y., & Nelson, M. T. (1989) · Science · doi:10.1126/science.2501869 · Cited by 1,192 · see citing works
Handbook of Physiology—The Cardiovascular System
Guyton, A. C. (1985) · Critical Care Medicine · doi:10.1097/00003246-198505000-00025 · Cited by 1,153 · see citing works
Blood Flow Regulation by <i>S</i> -Nitrosohemoglobin in the Physiological Oxygen Gradient
Stamler, J. S., Jia, L., Eu, J. P., McMahon, T. J., Demchenko, I. T., Bonaventura, J., Gernert, K., & Piantadosi, C. A. (1997) · Science · doi:10.1126/science.276.5321.2034 · Cited by 1,050 · see citing works
SIXTH GADDUM MEMORIAL LECTURE NATIONAL INSTITUTE FOR MEDICAL RESEARCH, MILL HILL, JANUARY 1977
Langer, S. Z. (1977) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1977.tb07526.x · Cited by 938 · see citing works
Handbook of Physiology. Section 12. Exercise: Regulation and Integration of Multiple Systems
Coast, J. R. (1997) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199703000-00021 · Cited by 915 · see citing works
Coronary Angioscopy in Patients with Unstable Angina Pectoris
Sherman, C. T., Litvack, F., Grundfest, W. S., Lee, M., Hickey, A., Chaux, A., Kass, R. M., Blanche, C., Matloff, J. M., Morgenstern, L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610093151501 · Cited by 869 · see citing works
Coronary physiology
Feigl, E. O. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.1.1 · Cited by 869 · see citing works
Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin
Cocks, T. M., & Angus, J. A. (1983) · Nature · doi:10.1038/305627a0 · Cited by 849 · see citing works
ATP-sensitive and inwardly rectifying potassium channels in smooth muscle
Quayle, J. M., Nelson, M. T., & Standen, N. B. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.1165 · Cited by 839 · see citing works
Exercise : regulation and integration of multiple systems
Rowell, L. B., & Shepherd, J. T. (1996) · Medical Entomology and Zoology · Cited by 810 · see citing works
Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.
Linder, L., Kiowski, W., Bühler, F. R., & Lüscher, T. F. (1990) · Circulation · doi:10.1161/01.cir.81.6.1762 · Cited by 797 · see citing works
Ventricular energetics
Suga, H. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.247 · Cited by 744 · see citing works
Cardiovascular Adaptations to Physical Training
Blomqvist, C. G., & Saltin, B. (1983) · Annual Review of Physiology · doi:10.1146/annurev.ph.45.030183.001125 · Cited by 706 · see citing works
Angiotensin II receptors
Singh, K. D., & Karnik, S. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816228-6.00020-9 · Cited by 705 · see citing works
PRESYNAPTIC RECEPTORS AND THEIR ROLE IN THE REGULATION OF TRANSMITTER RELEASE.
Langer, S., & Sz, L. (1977) · Cited by 612 · see citing works
Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels
Daut, J., Maier-Rudolph, W., von Beckerath, N., Mehrke, G., Günther, K., & Goedel-Meinen, L. (1990) · Science · doi:10.1126/science.2107575 · Cited by 593 · see citing works
Release of Prostaglandins and Thromboxane into the Coronary Circulation in Patients with Ischemic Heart Disease
Hirsh, P. D., Hillis, L. D., Campbell, W. B., Firth, B. G., & Willerson, J. T. (1981) · New England Journal of Medicine · doi:10.1056/nejm198103193041201 · Cited by 593 · see citing works
THE INFLUENCE OF THE INTERVAL BETWEEN BEATS ON MYOCARDIAL CONTRACTILITY
Koch‐Weser, J., & Blinks, J. R. (1963) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07048-6 · Cited by 578 · see citing works
Hemodynamic correlates of myocardial oxygen consumption during upright exercise
Kitamura, K., Jorgensen, C. R., Gobel, F. L., Taylor, H. L., & Wang, Y. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.32.4.516 · Cited by 575 · see citing works
Exercise‐induced arterial hypoxaemia in healthy human subjects at sea level.
Dempsey, J. A., Hanson, P., & Henderson, K. S. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015412 · Cited by 557 · see citing works
Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.
Nueten, J. M. V., Janssen, P. A. J., Beek, J. V., Xhonneux, R., Verbeuren, T. J., & Vanhoutte, P. M. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32655-8 · Cited by 520 · see citing works
Structural features of the athlete heart as defined by echocardiography
Maron, B. J. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80282-0 · Cited by 516 · see citing works
The erythrocyte as a regulator of vascular tone
Ellsworth, M. L., Forrester, T., Ellis, C. G., & Dietrich, H. H. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.6.h2155 · Cited by 508 · see citing works
Hemodynamic Predictors of Myocardial Oxygen Consumption During Static and Dynamic Exercise
NELSON, R. R., Gobel, F. L., Jorgensen, C. R., Wang, K., Wang, Y., & TAYLOR, H. L. (1974) · Circulation · doi:10.1161/01.cir.50.6.1179 · Cited by 500 · see citing works
CHEMICAL PHYSIOLOGY OF BLOOD FLOW REGULATION BY RED BLOOD CELLS: The Role of Nitric Oxide and S-Nitrosohemoglobin
Singel, D. J., & Stamler, J. S. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.67.060603.090918 · Cited by 481 · see citing works
Cardiovascular Adaptations to Physical Training
Scheuer, J., & Tipton, C. M. (1977) · Annual Review of Physiology · doi:10.1146/annurev.ph.39.030177.001253 · Cited by 478 · see citing works
Longitudinal Gradients in Periarteriolar Oxygen Tension
Duling, B. R., & Berne, R. M. (1970) · Circulation Research · doi:10.1161/01.res.27.5.669 · Cited by 468 · see citing works
Calcium-Activated Potassium Channels and the Regulation of Vascular Tone
Ledoux, J., Werner, M. E., Brayden, J. E., & Nelson, M. T. (2006) · Physiology · doi:10.1152/physiol.00040.2005 · Cited by 464 · see citing works
Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity.
Flavahan, N. A. (1992) · Circulation · doi:10.1161/01.cir.85.5.1927 · Cited by 454 · see citing works
Nitric oxide activity in the human coronary circulation. Impact of risk factors for coronary atherosclerosis.
Quyyumi, A. A., Dakak, N., Andrews, N. P., Husain, S., Arora, S., Gilligan, D. M., Panza, J. A., & Cannon, R. O. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117852 · Cited by 444 · see citing works
Effects on thermal stress and exercise on blood volume in humans
Harrison, M. H. (1985) · Physiological Reviews · doi:10.1152/physrev.1985.65.1.149 · Cited by 440 · see citing works
Left ventricular performance in normal subjects: a comparison of the responses to exercise in the upright and supine positions.
Poliner, L. R., DEHMER, G. J., Lewis, S. E., Parkey, R. W., Blomqvist, C. G., & Willerson, J. T. (1980) · Circulation · doi:10.1161/01.cir.62.3.528 · Cited by 408 · see citing works
Pressure-flow relations in coronary circulation
Hoffman, J. I. E., & Spaan, J. A. E. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.331 · Cited by 396 · see citing works
Cardiovascular Control Mechanisms in the Conscious State
Vatner, S. F., & D, E. B. M. (1975) · New England Journal of Medicine · doi:10.1056/nejm197511062931906 · Cited by 394 · see citing works
Interaction of pressure- and flow-induced responses in porcine coronary resistance vessels
Kuo, L., Chilian, W. M., & Davis, M. J. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.6.h1706 · Cited by 392 · see citing works
Microvascular distribution of coronary vascular resistance in beating left ventricle
Chilian, W. M., Eastham, C. L., & Marcus, M. L. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.251.4.h779 · Cited by 379 · see citing works
Impaired Endothelium-Dependent Vasodilation of Coronary Resistance Vessels Is Associated With Exercise-Induced Myocardial Ischemia
Zeiher, A. M., Krause, T., Schächinger, V., Minners, J., & Moser, E. A. (1995) · Circulation · doi:10.1161/01.cir.91.9.2345 · Cited by 364 · see citing works
Adenosine as inhibitor of myocardial effects of catecholamines
Schrader, J., Baumann, G., & Gerlach, E. (1977) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00582203 · Cited by 361 · see citing works
Inhibition of coronary blood flow by a vascular waterfall mechanism.
Downey, J. M., & Kirk, E. S. (1975) · Circulation Research · doi:10.1161/01.res.36.6.753 · Cited by 345 · see citing works
Heart Physiology: From Cell to Circulation
Opie, L. H. (1998) · Cited by 339 · see citing works
Understanding the coronary circulation through studies at the microvascular level.
Marcus, M. L., Chilian, W. M., Kanatsuka, H., Dellsperger, K. C., Eastham, C. L., & Lamping, K. G. (1990) · Circulation · doi:10.1161/01.cir.82.1.1 · Cited by 331 · see citing works
Diastolic coronary artery pressure-flow relations in the dog.
Bellamy, R. F. (1978) · Circulation Research · doi:10.1161/01.res.43.1.92 · Cited by 301 · see citing works
Matching coronary blood flow to myocardial oxygen consumption.
Tune, J., Gorman, M. W., & Feigl, E. (2004) · Journal of applied physiology · doi:10.1152/japplphysiol.01345.2003 · Cited by 298 · see citing works
Effect of Coronary Vasodilator Drugs on Retrograde Flow in Areas of Chronic Myocardial Ischemia
Fam, W. M., & McGregor, M. (1964) · Circulation Research · doi:10.1161/01.res.15.4.355 · Cited by 287 · see citing works
K+ channel modulation in arterial smooth muscle
STANDEN, & QUAYLE (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.00433.x · Cited by 285 · see citing works
Rapid changes in left ventricular dimensions and mass in response to physical conditioning and deconditioning
Ehsani, A. A., Hagberg, J. M., & Hickson, R. C. (1978) · The American Journal of Cardiology · doi:10.1016/0002-9149(78)90984-0 · Cited by 285 · see citing works
Functional Roles Of KATP Channels In Vascular Smooth Muscle
Brayden, J. E. (2002) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2002.03650.x · Cited by 283 · see citing works
EFFECT OF NITRATES AND OTHER CORONARY DILATORS ON LARGE AND SMALL CORONARY VESSELS: AN HYPOTHESIS FOR THE MECHANISM OF ACTION OF NITRATES
Winbury, M. M., Howe, B. B., & HEFNER, M. A. (1969) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28302-1 · Cited by 278 · see citing works
Control of myocardial oxygen consumption: relative influence of contractile state and tension development
Graham, T. P., Covell, J. W., Sonnenblick, E. H., Ross, J., & D, E. B. M. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105734 · Cited by 276 · see citing works
Nitric oxide synthesized from L‐arginine regulates vascular tone in the coronary circulation of the rabbit
Amezcua, J. L., Palmer, R. M. J., de Souza, B. M., & Moncada, S. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb12569.x · Cited by 276 · see citing works
Competition between sympathetic vasoconstriction and metabolic vasodilation in the canine coronary circulation.
Mohrman, D. E., & Feigl, E. O. (1978) · Circulation Research · doi:10.1161/01.res.42.1.79 · Cited by 274 · see citing works
Protein kinases: tuners of the BKCa channel in smooth muscle
Schubert, R., & Nelson, M. T. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01775-2 · Cited by 274 · see citing works
Effect of Exercise and Coronary Artery Narrowing on Coronary Collateral Circulation
ECKSTEIN, R. W. (1957) · Circulation Research · doi:10.1161/01.res.5.3.230 · Cited by 273 · see citing works
Cross-Talk Between Cardiac Muscle and Coronary Vasculature
Westerhof, N., Boer, C., Lamberts, R. R., & Sipkema, P. (2006) · Physiological Reviews · doi:10.1152/physrev.00029.2005 · Cited by 273 · see citing works
Potassium Channel Function in Vascular Disease
Sobey, C. G. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.1.28 · Cited by 271 · see citing works
α-Adrenergic Coronary Vasoconstriction and Myocardial Ischemia in Humans
Heusch, G., Baumgart, D., Camici, P. G., Chilian, W. M., Gregorini, L., Hess, O. M., Indolfi, C., & Rimoldi, O. E. (2000) · Circulation · doi:10.1161/01.cir.101.6.689 · Cited by 261 · see citing works
Skeletal muscle blood flow capacity: role of muscle pump in exercise hyperemia
Laughlin, M. H. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.253.5.h993 · Cited by 249 · see citing works
Vasopressin causes endothelium-dependent relaxations of the canine basilar artery.
Katušić, Z. S., Shepherd, J. T., & Vanhoutte, P. M. (1984) · Circulation Research · doi:10.1161/01.res.55.5.575 · Cited by 246 · see citing works
Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia?
Rowell, L. B., Saltin, B., Kiens, B., & Christensen, N. J. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.251.5.h1038 · Cited by 242 · see citing works
Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans.
Lefroy, D. C., Crake, T., Uren, N. G., Davies, G. J., & Maseri, A. (1993) · Circulation · doi:10.1161/01.cir.88.1.43 · Cited by 237 · see citing works
Effects of exercise on myocardial force-velocity relations in intact unanesthetized man: relative roles of changes in heart rate, sympathetic activity, and ventricular dimensions.
Sonnenblick, E. H., D, E. B. M., Williams, J. F., & Glick, G. (1965) · Journal of Clinical Investigation · doi:10.1172/jci105312 · Cited by 233 · see citing works
Effect of Exercise on Cardiac Output, Left Coronary Flow and Myocardial Metabolism in the Unanesthetized Dog
KHOURI, E. M., Gregg, D. E., & Rayford, C. R. (1965) · Circulation Research · doi:10.1161/01.res.17.5.427 · Cited by 231 · see citing works
Endothelial modulation of coronary tone
Bassenge, E., & Busse, R. (1988) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(88)90003-5 · Cited by 223 · see citing works
The effects of cardiac sympathetic nerve stimulation on perfusion of stenotic coronary arteries in the dog.
Heusch, G., & Deußen, A. (1983) · Circulation Research · doi:10.1161/01.res.53.1.8 · Cited by 217 · see citing works
Redistribution of coronary microvascular resistance produced by dipyridamole
Chilian, W. M., Layne, S. M., Klausner, E. C., Eastham, C. L., & Marcus, M. L. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.256.2.h383 · Cited by 216 · see citing works
Transmural myocardial perfusion
Hoffman, J. I. E. (1987) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(87)90016-8 · Cited by 214 · see citing works
Regulation of adenosine formation by the heart.
SPARKS, H. V., & Bardenheuer, H. J. (1986) · Circulation Research · doi:10.1161/01.res.58.2.193 · Cited by 214 · see citing works
CORONARY CIRCULATION DURING HEAVY EXERCISE IN CONTROL SUBJECTS AND PATIENTS WITH CORONARY HEART DISEASE
Holmberg, S., Serźysko, W., & Varnauskas, E. (1971) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1971.tb07462.x · Cited by 210 · see citing works
Total and Regional Myocardial Blood Flow Measurements with 25µ, 15µ, 9µ, and Filtered 1-10µ Diameter Microspheres and Antipyrine in Dogs and Sheep
UTLEY, J., Carlson, E. L., Hoffman, J. I. E., Martínez, H. M., & Buckberg, G. D. (1974) · Circulation Research · doi:10.1161/01.res.34.3.391 · Cited by 210 · see citing works
Hypoxia stimulates release of endothelium-derived relaxant factor
Pohl, U., & Busse, R. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.256.6.h1595 · Cited by 207 · see citing works
Distribution of blood flow in muscles of miniature swine during exercise
Armstrong, R. B., Delp, M. D., Goljan, E. F., & Laughlin, M. H. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.62.3.1285 · Cited by 206 · see citing works
Role of Endogenous Bradykinin in Human Coronary Vasomotor Control
Groves, P. H., Kurz, S. K., Just, H., & Drexler, H. (1995) · Circulation · doi:10.1161/01.cir.92.12.3424 · Cited by 205 · see citing works
Coronary Vasoconstrictor Effect of Indomethacin in Patients with Coronary-Artery Disease
Friedman, P. L., Brown, E. J., Gunther, S., Alexander, R. W., Barry, W. H., Mudge, G. H., & Grossman, W. (1981) · New England Journal of Medicine · doi:10.1056/nejm198111123052002 · Cited by 205 · see citing works
Effect of maximal coronary vasodilation on transmural myocardial perfusion during tachycardia in the awake dog.
Bache, R. J., & Cobb, F. R. (1977) · Circulation Research · doi:10.1161/01.res.41.5.648 · Cited by 204 · see citing works
Self-citation
cAMP-Independent Dilation of Coronary Arterioles to Adenosine
Hein, T. W., & Kuo, L. (1999) · Circulation Research · doi:10.1161/01.res.85.7.634 · Cited by 203 · see citing works
Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts
Martínez‐López, J., Lorell, B. H., Ingelfinger, J. R., Weinberg, E. O., Schunkert, H., Diamant, D., & Tang, S. S. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.2.h844 · Cited by 202 · see citing works
Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.
Gruber, H. E., Hoffer, M. E., McAllister, D. R., Laikind, P. K., Lane, T. A., Schmid-Schöenbein, G. W., & Engler, R. L. (1989) · Circulation · doi:10.1161/01.cir.80.5.1400 · Cited by 201 · see citing works
Transcardiac serotonin concentration is increased in selected patients with limiting angina and complex coronary lesion morphology.
Berg, E. K. V. D., Schmitz, J. M., Benedict, C. R., Malloy, C. R., Willerson, J. T., & DEHMER, G. J. (1989) · Circulation · doi:10.1161/01.cir.79.1.116 · Cited by 201 · see citing works
Relationship between blood flow to ischemic regions and extent of myocardial infarction. Serial measurement of blood flow to ischemic regions in dogs.
Rivas, F., Cobb, F. R., Bache, R. J., & Greenfield, J. C. (1976) · Circulation Research · doi:10.1161/01.res.38.5.439 · Cited by 199 · see citing works
Self-citation
Contribution of Vasodilator Prostanoids and Nitric Oxide to Resting Flow, Metabolic Vasodilation, and Flow-Mediated Dilation in Human Coronary Circulation
Duffy, S. J., Castle, S., Harper, R. W., & Meredith, I. T. (1999) · Circulation · doi:10.1161/01.cir.100.19.1951 · Cited by 198 · see citing works
ATP-Sensitive K+Channels, Adenosine, and Nitric Oxide–Mediated Mechanisms Account for Coronary Vasodilation During Exercise
Ishibashi, Y., Duncker, D. J., Zhang, J. J., & Bache, R. J. (1998) · Circulation Research · doi:10.1161/01.res.82.3.346 · Cited by 197 · see citing works
Self-citation
Coronary diastolic pressure-flow relation and zero flow pressure explained on the basis of intramyocardial compliance.
Spaan, J. A. E. (1985) · Circulation Research · doi:10.1161/01.res.56.3.293 · Cited by 196 · see citing works
Function and Production of Nitric Oxide in the Coronary Circulation of the Conscious Dog During Exercise
Bernstein, R. D., Ochoa, F., Xu, X., Forfia, P. R., Shen, W., Thompson, C. I., & Hintze, T. H. (1996) · Circulation Research · doi:10.1161/01.res.79.4.840 · Cited by 192 · see citing works
5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries
Cohen, R. A., Shepherd, J. T., & Vanhoutte, P. M. (1983) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1983.245.6.h1077 · Cited by 191 · see citing works
Control of Blood Flow to Cardiac and Skeletal Muscle During Exercise
Laughlin, M. H., Korthuis, R. J., Duncker, D. J., & Bache, R. J. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp120116 · Cited by 189 · see citing works
Self-citation
Regional myocardial blood flow during exercise in dogs with chronic left ventricular hypertrophy.
Bache, R. J., Vrobel, T. R., Ring, W. S., Emery, R. W., & Andersen, R. W. (1981) · Circulation Research · doi:10.1161/01.res.48.1.76 · Cited by 188 · see citing works
Self-citation
Maxi K+ channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells
Taniguchi, J., Furukawa, K. I., & Shigekawa, M. (1993) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374390 · Cited by 188 · see citing works
Role of Nitric Oxide in the Coronary Microvascular Responses to Adenosine and Increased Metabolic Demand
Jones, C. J. H., Kuo, L., Davis, M. J., DeFily, D. V., & Chilian, W. M. (1995) · Circulation · doi:10.1161/01.cir.91.6.1807 · Cited by 187 · see citing works
The experimental production of coronary artery insufficiency and occlusion
Litvak, J., Siderides, L. E., & Vineberg, A. (1957) · American Heart Journal · doi:10.1016/0002-8703(57)90359-9 · Cited by 186 · see citing works
cAMP-Dependent Vasodilators Cross-Activate the cGMP-Dependent Protein Kinase to Stimulate BKCaChannel Activity in Coronary Artery Smooth Muscle Cells
White, R. E., Kryman, J. P., El‐Mowafy, A. M., Han, G., & Carrier, G. O. (2000) · Circulation Research · doi:10.1161/01.res.86.8.897 · Cited by 184 · see citing works
Modification of myofibrillar responsiveness to Ca++ as an inotropic mechanism.
Blinks, J. R., & Endoh, M. (1986) · PubMed · Cited by 183 · see citing works
Endothelium-dependent relaxation competes with alpha 1- and alpha 2-adrenergic constriction in the canine epicardial coronary microcirculation.
Jones, C. J., DeFily, D. V., Patterson, J. L., & Chilian, W. M. (1993) · Circulation · doi:10.1161/01.cir.87.4.1264 · Cited by 182 · see citing works
Cellular mechanisms of insulin resistance in humans
Shulman, G. I. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00350-1 · Cited by 178 · see citing works
Effects of Moderate Exercise Training on Thallium Uptake and Contractile Response to Low-Dose Dobutamine of Dysfunctional Myocardium in Patients With Ischemic Cardiomyopathy
Belardinelli, R., Georgiou, D., Ginzton, L. E., Cianci, G., & Purcaro, A. (1998) · Circulation · doi:10.1161/01.cir.97.6.553 · Cited by 178 · see citing works
Hydrogen Peroxide
Saitoh, S., Zhang, C., Tune, J. D., Potter, B. J., Kiyooka, T., Rogers, P. A., Knudson, J. D., Dick, G. M., Swafford, A. N., & Chilian, W. M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000249408.55796.da · Cited by 176 · see citing works
Biochemical evidence of platelet activation in patients with persistent unstable angina
Hamm, C. W., Lorenz, R. L., Bleifeld, W., Kupper, W., Wober, W., & Weber, P. C. (1987) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(87)80336-4 · Cited by 175 · see citing works
The role of intracoronary thrombus in unstable angina: angiographic assessment and thrombolytic therapy during ongoing anginal attacks.
Gotoh, K., Minamino, T., Katoh, O., Hamano, Y., Fukui, S., Hori, M., Kusuoka, H., Mishima, M., Inoue, M., & Kamada, T. (1988) · Circulation · doi:10.1161/01.cir.77.3.526 · Cited by 173 · see citing works
18 F-2-Deoxyglucose Deposition and Regional Flow in Pigs With Chronically Dysfunctional Myocardium
Fallavollita, J. A., Perry, B. J., & Canty, J. M. (1997) · Circulation · doi:10.1161/01.cir.95.7.1900 · Cited by 171 · see citing works
Cardiovascular adjustments to exercise: Hemodynamics and mechanisms
Vatner, S. F., & Pagani, M. (1976) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(76)90018-9 · Cited by 170 · see citing works
Heart physiology and pathophysiology
Sperelakis, N. (2001) · Cited by 169 · see citing works
POTASSIUM CHANNELS IN VASCULAR SMOOTH MUSCLE
Brayden, J. E. (1996) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1996.tb01172.x · Cited by 168 · see citing works
Exercise training in swine promotes growth of arteriolar bed and capillary angiogenesis in heart
White, F. C., Bloor, C. M., McKirnan, M. D., & Carroll, S. M. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.3.1160 · Cited by 168 · see citing works
The vascular supply of the left ventricular wall
Estes, E. H., Entman, M. L., Dixon, H. B., & Hackel, D. B. (1966) · American Heart Journal · doi:10.1016/0002-8703(66)90657-0 · Cited by 167 · see citing works
Supply-to-demand ratio for oxygen determines formation of adenosine by the heart
Bardenheuer, H., & Schrader, J. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.2.h173 · Cited by 167 · see citing works
ATP-sensitive potassium channel is essential to maintain basal coronary vascular tone in vivo
Samaha, F. F., Heineman, F. W., İnce, C., Fleming, J., & Balaban, R. S. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.262.5.c1220 · Cited by 166 · see citing works
Cardiovascular Pharmacology of Propranolol in Man
Wolfson, S., & Gorlin, R. (1969) · Circulation · doi:10.1161/01.cir.40.4.501 · Cited by 165 · see citing works
Exercise and autonomic function
Goldsmith, R. L., Bloomfield, D. M., & Rosenwinkel, E. T. (2000) · Coronary Artery Disease · doi:10.1097/00019501-200003000-00007 · Cited by 163 · see citing works
Acidosis-Induced Coronary Arteriolar Dilation Is Mediated by ATP-Sensitive Potassium Channels in Vascular Smooth Muscle
Ishizaka, H., & Kuo, L. (1996) · Circulation Research · doi:10.1161/01.res.78.1.50 · Cited by 162 · see citing works
Blockade of the ATP-sensitive potassium channel modulates reactive hyperemia in the canine coronary circulation.
Aversano, T. R., Ouyang, P., & SILVERMAN, H. J. (1991) · Circulation Research · doi:10.1161/01.res.69.3.618 · Cited by 161 · see citing works
Microvascular pressures and resistances in the left ventricular subepicardium and subendocardium.
Chilian, W. M. (1991) · Circulation Research · doi:10.1161/01.res.69.3.561 · Cited by 161 · see citing works
Effect of Propranolol on Myocardial Oxygen Consumption and Its Hemodynamic Correlates during Upright Exercise
Jorgensen, C. R., Wang, K., Wang, Y., Gobel, F. L., NELSON, R. R., TAYLOR, H. L., Gams, F. R., & Vilandre, J. (1973) · Circulation · doi:10.1161/01.cir.48.6.1173 · Cited by 161 · see citing works
Cardiac and Coronary Prostaglandin Synthesis and Function
Needleman, P., & Kaley, G. (1978) · New England Journal of Medicine · doi:10.1056/nejm197805182982005 · Cited by 159 · see citing works
Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve.
Canty, J. M., & Klocke, F. J. (1985) · Circulation · doi:10.1161/01.cir.71.2.370 · Cited by 159 · see citing works
Training induces nonuniform increases in eNOS content along the coronary arterial tree
Laughlin, M. H., Pollock, J. S., Amann, J. F., HOLLIS, M., Woodman, C. R., & Price, E. M. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.2.501 · Cited by 159 · see citing works
Vasodilator responses of coronary resistance arteries of exercise-trained pigs.
Muller‐Delp, J. M., Myers, P. R., & Laughlin, M. H. (1994) · Circulation · doi:10.1161/01.cir.89.5.2308 · Cited by 157 · see citing works
Divergent Roles of Angiotensin II AT 1 and AT 2 Receptors in Modulating Coronary Microvascular Function
Zhang, C., Hein, T. W., Wang, W., & Kuo, L. (2003) · Circulation Research · doi:10.1161/01.res.0000056759.53828.2c · Cited by 156 · see citing works
Nitric oxide is a mediator of hypoxic coronary vasodilatation. Relation to adenosine and cyclooxygenase-derived metabolites.
Park, K. H., Rubin, L. E., Gross, S. S., & Levi, R. (1992) · Circulation Research · doi:10.1161/01.res.71.4.992 · Cited by 155 · see citing works
Metabolic response to prolonged reduction of myocardial blood flow distal to a severe coronary artery stenosis.
Fedele, F., Gewirtz, H., Capone, R. J., Sharaf, B. L., & Most, A. S. (1988) · Circulation · doi:10.1161/01.cir.78.3.729 · Cited by 154 · see citing works
Morphometry of exercise-induced right ventricular hypertrophy in the rat.
Anversa, P., Levický, V., Beghi, C., McDonald, S. L., & Kikkawa, Y. (1983) · Circulation Research · doi:10.1161/01.res.52.1.57 · Cited by 154 · see citing works
Redox Modulation of Vascular Tone
Gutterman, D. D., Miura, H., & Liu, Y. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000158497.09626.3b · Cited by 152 · see citing works
Cardiovascular Performance of Alaska Sled Dogs during Exercise
Citters, R. L. V., & FRANKLIN, D. L. (1969) · Circulation Research · doi:10.1161/01.res.24.1.33 · Cited by 151 · see citing works
Effects of unilateral stellectomy upon cardiac performance during exercise in dogs.
Schwartz, P. J., & STONE, H. L. (1979) · Circulation Research · doi:10.1161/01.res.44.5.637 · Cited by 151 · see citing works
Resting Myocardial Blood Flow Is Impaired in Hibernating Myocardium
Selvanayagam, J. B., Jerosch‐Herold, M., Porto, I., Sheridan, D. C., Cheng, A. S. H., Petersen, S. E., Searle, N., Channon, K. M., BANNING, A. P., & Neubauer, S. (2005) · Circulation · doi:10.1161/circulationaha.105.549170 · Cited by 150 · see citing works
Exercise training-induced coronary vascular adaptation
Laughlin, M. H., & McAllister, R. M. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.6.2209 · Cited by 149 · see citing works
Effects of age and exercise on the extent of the myocardial capillary bed
Tomanek, R. J. (1970) · The Anatomical Record · doi:10.1002/ar.1091670106 · Cited by 148 · see citing works
Ramiprilat increases bradykinin outflow from isolated hearts of rat
Baumgarten, C. R., Linz, W., Kunkel, G., Schölkens, B. A., & Wiemer, G. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb12797.x · Cited by 148 · see citing works
Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels
Jackson, W. F., Konig, A., Dambacher, T., & Busse, R. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.264.1.h238 · Cited by 148 · see citing works
Myocardial Ischemia Caused by Distal Coronary-Artery Constriction in Stable Angina Pectoris
Pupita, G., Maseri, A., Kaski, J. C., Galassi, A. R., Gavrielides, S., Davies, G., & Crea, F. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008233230804 · Cited by 148 · see citing works
Oxygen transport during exercise in large mammals. I. Adaptive variation in oxygen demand
Jones, J. H., Longworth, K. E., Lindholm, A., Conley, K. E., Karas, R. H., Kayar, S. R., & Taylor, C. R. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.2.862 · Cited by 147 · see citing works
Red Blood Cell–Derived ATP as a Regulator of Skeletal Muscle Perfusion
Ellsworth, M. L. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000106284.80300.b2 · Cited by 147 · see citing works
Role of K+ATP channels in coronary vasodilation during exercise.
Duncker, D. J., van Zon, N. S., Altman, J. D., Pavek, T., & Bache, R. J. (1993) · Circulation · doi:10.1161/01.cir.88.3.1245 · Cited by 145 · see citing works
Self-citation
Transmural distribution of myocardial blood flow during systole in the awake dog.
Hess, D., & Bache, R. J. (1976) · Circulation Research · doi:10.1161/01.res.38.1.5 · Cited by 145 · see citing works
Self-citation
Coronary pressure-flow relationships. Controversial issues and probable implications.
Klocke, F. J., Mates, R. E., Canty, J. M., & Ellis, A. K. (1985) · Circulation Research · doi:10.1161/01.res.56.3.310 · Cited by 145 · see citing works
Diastolic coronary artery pressure-flow relations in the dog.
FBellamy, R. (1978) · Circulation Research · Cited by 143 · see citing works
Regulation of coronary blood flow: coordination of heterogeneous control mechanisms in vascular microdomains
Jones, C. J., Kuo, L., Davis, M. J., & Chilian, W. M. (1995) · Cardiovascular Research · doi:10.1016/s0008-6363(96)88626-3 · Cited by 140 · see citing works
Comparison of the effects of increased myocardial oxygen consumption and adenosine on the coronary microvascular resistance.
Kanatsuka, H., Lamping, K. G., Eastham, C. L., Dellsperger, K. C., & Marcus, M. L. (1989) · Circulation Research · doi:10.1161/01.res.65.5.1296 · Cited by 139 · see citing works
Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans
(1994) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1016/1053-0770(94)90027-2 · Cited by 138 · see citing works
The Effects of Nitroglycerin on Coronary Collaterals and Myocardial Contractility
Cohen, M. V., Downey, J. M., Sonnenblick, E. H., & Kirk, E. S. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107479 · Cited by 137 · see citing works
Cardiac microdialysis to estimate interstitial adenosine and coronary blood flow
Wylen, D. G. V., Willis, J., Sodhi, J., Weiss, R. J., Lasley, R. D., & Mentzer, R. M. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.258.6.h1642 · Cited by 137 · see citing works
PATTERNS OF HUMAN MYOCARDIAL OXYGEN EXTRACTION DURING REST AND EXERCISE*
Messer, J. V., Wagman, R. J., Levine, H. J., Neill, W. A., Krasnow, N., & Gorlin, R. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104531 · Cited by 136 · see citing works
The paradox of adrenergic coronary vasoconstriction.
Feigl, E. O. (1987) · Circulation · doi:10.1161/01.cir.76.4.737 · Cited by 135 · see citing works
Physical Training in the Management of Coronary Artery Disease
CLAUSEN, J. P., Larsen, O. A., & Trap‐Jensen, J. (1969) · Circulation · doi:10.1161/01.cir.40.2.143 · Cited by 135 · see citing works
Endothelium-derived bradykinin is responsible for the increase in calcium produced by angiotensin-converting enzyme inhibitors in human endothelial cells
Busse, R., & Lamontagne, D. (1991) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00167392 · Cited by 133 · see citing works
Effects of preload on the transmural distribution of perfusion and pressure-flow relationships in the canine coronary vascular bed.
Ellis, A. K., & Klocke, F. J. (1980) · Circulation Research · doi:10.1161/01.res.46.1.68 · Cited by 133 · see citing works
Intracoronary alpha 2-adrenergic receptor blockade attenuates ischemia in conscious dogs during exercise.
Seitelberger, R., Guth, B. D., Heusch, G., Lee, J., Katayama, K., & ROSS, J. R. (1988) · Circulation Research · doi:10.1161/01.res.62.3.436 · Cited by 133 · see citing works
alpha-Adrenoceptor attenuation of the coronary vascular response to severe exercise in the conscious dog.
Murray, P. A., & Vatner, S. F. (1979) · Circulation Research · doi:10.1161/01.res.45.5.654 · Cited by 132 · see citing works
Effect of inhibition of nitric oxide formation on coronary blood flow during exercise in the dog
Altman, J. D., Kinn, J. W., Duncker, D. J., & Bache, R. J. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.1.119 · Cited by 129 · see citing works
Self-citation
Removal of the endothelium potentiates canine large coronary artery constrictor responses to 5-hydroxytryptamine in vivo.
Lamping, K. G., Marcus, M. L., & Dole, W. P. (1985) · Circulation Research · doi:10.1161/01.res.57.1.46 · Cited by 128 · see citing works
Exercise-induced reduction in myocardial infarct size after coronary artery occlusion in the rat.
McElroy, C. L., Gissen, S. A., & Fishbein, M. C. (1978) · Circulation · doi:10.1161/01.cir.57.5.958 · Cited by 128 · see citing works
Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart.
Alexander, R. W., Kent, K. M., Pisano, J. J., Keiser, H. R., & Cooper, T. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108034 · Cited by 128 · see citing works
Studies on the regulation of myocardial blood flow in man
Heiss, H., BARMEYER, J., Wink, K., van Hell, G., Cerny, F., Keul, J., & Reindell, H. (1976) · Basic Research in Cardiology · doi:10.1007/bf01906411 · Cited by 127 · see citing works
Development of coronary collateral circulation in left circumflex Ameroid-occluded swine myocardium
Roth, D. M., Maruoka, Y., Rogers, J., White, F. C., Longhurst, J. C., & Bloor, C. M. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.253.5.h1279 · Cited by 126 · see citing works
Influence of altitude exposure on coronary flow reserve
Wyss, C. A., Koepfli, P., Fretz, G., Seebauer, M., Schirlo, C., & Kaufmann, P. A. (2003) · Circulation · doi:10.1161/01.cir.0000087432.63671.2e · Cited by 125 · see citing works
Modulation of coronary autoregulatory responses by nitric oxide. Evidence for flow-dependent resistance adjustments in conscious dogs.
Smith, T. P., & Canty, J. M. (1993) · Circulation Research · doi:10.1161/01.res.73.2.232 · Cited by 125 · see citing works
Hyperpolarizing Factors
Quilley, J., Fulton, D. J., & McGiff, J. C. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00039-7 · Cited by 125 · see citing works
Control of Coronary Blood Flow during Exercise
Tune, J. D., Richmond, K. N., Gorman, M. W., & Feigl, E. O. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700404 · Cited by 124 · see citing works
Ideas about control of skeletal and cardiac muscle blood flow (1876–2003): cycles of revision and new vision
Rowell, L. B. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01220.2003 · Cited by 124 · see citing works
Role of ATP-sensitive potassium channels in coronary microvascular autoregulatory responses.
Komaru, T., Lamping, K., Eastham, C., & Dellsperger, K. (1991) · Circulation Research · doi:10.1161/01.res.69.4.1146 · Cited by 122 · see citing works
Gas Exchange in Exercise
Cerretelli, P., & di Prampero, P. E. (1987) · Comprehensive physiology · doi:10.1002/cphy.cp030416 · Cited by 121 · see citing works
Mechanisms of Oxygen Demand/Supply Balance in the Right Ventricle
Zong, P., Tune, J. D., & Downey, H. F. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000801 · Cited by 121 · see citing works
Heterogeneous microvascular coronary alpha-adrenergic vasoconstriction.
Chilian, W. M., Layne, S. M., Eastham, C. L., & Marcus, M. L. (1989) · Circulation Research · doi:10.1161/01.res.64.2.376 · Cited by 121 · see citing works
Left Ventricular Response to Severe Exertion in Untethered Dogs
Vatner, S. F., FRANKLIN, D. L., Higgins, C. B., Patrick, T. A., & D, E. B. M. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107132 · Cited by 121 · see citing works
Heterogeneous changes in epimyocardial microvascular size during graded coronary stenosis. Evidence of the microvascular site for autoregulation.
Kanatsuka, H., Lamping, K. G., Eastham, C. L., & Marcus, M. L. (1990) · Circulation Research · doi:10.1161/01.res.66.2.389 · Cited by 121 · see citing works
Effects of exercise and its cessation on the heart and its blood supply.
Leon, A. S., & Bloor, C. M. (1968) · Journal of Applied Physiology · doi:10.1152/jappl.1968.24.4.485 · Cited by 121 · see citing works
Regional changes in capillary supply in skeletal muscle of high-intensity endurance-trained rats
Gute, D. C., Fraga, C., Laughlin, M. H., & Amann, J. F. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.2.619 · Cited by 121 · see citing works
Functional distribution of alpha 1- and alpha 2-adrenergic receptors in the coronary microcirculation.
Chilian, W. M. (1991) · Circulation · doi:10.1161/01.cir.84.5.2108 · Cited by 120 · see citing works
Coronary microvascular responses to reductions in perfusion pressure. Evidence for persistent arteriolar vasomotor tone during coronary hypoperfusion.
Chilian, W. M., & Layne, S. M. (1990) · Circulation Research · doi:10.1161/01.res.66.5.1227 · Cited by 120 · see citing works
Autonomic Control of Vasomotion in the Porcine Coronary Circulation During Treadmill Exercise
Duncker, D. J., Stubenitsky, R., & Verdouw, P. D. (1998) · Circulation Research · doi:10.1161/01.res.82.12.1312 · Cited by 120 · see citing works
Self-citation
Intramural Pressure in the Left Ventricle of the Dog
Brandi, G., & McGregor, M. (1969) · Cardiovascular Research · doi:10.1093/cvr/3.4.472 · Cited by 119 · see citing works
Contractile Element Work: A Major Determinant of Myocardial Oxygen Consumption*
Britman, N. A., & Levine, H. J. (1964) · Journal of Clinical Investigation · doi:10.1172/jci105015 · Cited by 119 · see citing works
Intracoronary adenosine deaminase reduces canine myocardial reactive hyperemia.
Saito, D., Steinhart, C. R., Nixon, D. G., & Olsson, R. A. (1981) · Circulation Research · doi:10.1161/01.res.49.6.1262 · Cited by 116 · see citing works
The effect of physical training upon the mechanical and metabolic performance of the rat heart
Penpargkul, S., & Scheuer, J. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106404 · Cited by 116 · see citing works
Endogenous adenosine mediates coronary vasodilation during exercise after K(ATP)+ channel blockade.
Duncker, D. J., van Zon, N. S., Pavek, T., Herrlinger, S. K., & Bache, R. J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117653 · Cited by 115 · see citing works
Self-citation
Why are circulating concentrations of endothelin-1 so low?
Frelin, C., & Guédin, D. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.11.1613 · Cited by 114 · see citing works
K+Currents in Human Coronary Artery Vascular Smooth Muscle Cells
Gollasch, M., Ried, C., Bychkov, R., Luft, F. C., & Haller, H. G. (1996) · Circulation Research · doi:10.1161/01.res.78.4.676 · Cited by 114 · see citing works
Prostaglandins and the control of blood flow in the canine myocardium.
Hintze, T. H., & Kaley, G. (1977) · Circulation Research · doi:10.1161/01.res.40.3.313 · Cited by 114 · see citing works
Persistence of coronary vasodilator reserve despite functionally significant flow reduction
Aversano, T. R., & Becker, L. C. (1985) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1985.248.3.h403 · Cited by 114 · see citing works
Plasma ATP during exercise: possible role in regulation of coronary blood flow
Farias, M., Gorman, M. W., Savage, M. V., & Feigl, E. O. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00983.2004 · Cited by 113 · see citing works
Hemodynamic and Coronary Effects of the Endothelin Antagonist Bosentan in Patients With Coronary Artery Disease
Wenzel, R. R., Fleisch, M., Shaw, S., Noll, G., KAUFMANN, U. P., Schmitt, R., Jones, C. R., Clozel, M., Meier, B., & Lüscher, T. F. (1998) · Circulation · doi:10.1161/01.cir.98.21.2235 · Cited by 113 · see citing works
Adrenergic coronary vasoconstriction helps maintain uniform transmural blood flow distribution during exercise.
Huang, A. H., & Feigl, E. O. (1988) · Circulation Research · doi:10.1161/01.res.62.2.286 · Cited by 113 · see citing works
The Effect of Exercise on Coronary Blood Flow, Myocardial Oxygen Consumption and Cardiac Efficiency in Man
LOMBARDO, T. A., Rose, L. B., Taeschler, M., TULUY, S., & Bing, R. J. (1953) · Circulation · doi:10.1161/01.cir.7.1.71 · Cited by 112 · see citing works
Contractility is the main determinant of coronary systolic flow impediment
Krams, R., Sipkema, P., Zegers, J. G., & Westerhof, N. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.257.6.h1936 · Cited by 112 · see citing works
Neural Control of Coronary Blood Flow
Feigl, E. O. (1998) · Journal of Vascular Research · doi:10.1159/000025569 · Cited by 111 · see citing works
Distribution of myocardial blood flow in the exercising dog with restricted coronary artery inflow.
Ball, R. M., & Bache, R. J. (1976) · Circulation Research · doi:10.1161/01.res.38.2.60 · Cited by 111 · see citing works
Self-citation
Hibernating Myocardium Retains Metabolic and Contractile Reserve Despite Regional Reductions in Flow, Function, and Oxygen Consumption at Rest
Fallavollita, J. A., Malm, B. J., & Canty, J. M. (2003) · Circulation Research · doi:10.1161/01.res.0000049104.57549.03 · Cited by 111 · see citing works
H2O2-induced redox-sensitive coronary vasodilation is mediated by 4-aminopyridine-sensitive K+channels
Rogers, P. A., Dick, G. M., Knudson, J. D., Focardi, M., Bratz, I. N., Swafford, A. N., Saitoh, S., Tune, J. D., & Chilian, W. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00172.2006 · Cited by 110 · see citing works
Effect of increased blood fluidity through hemodilution on general circulation at rest and during exercise in dogs
von Restorff, W., Höfling, B., Holtz, J., & Bassenge, E. (1975) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584542 · Cited by 109 · see citing works
Role of endothelium-derived relaxing factor in parasympathetic coronary vasodilation
Broten, T. P., Miyashiro, J. K., Moncada, S., & Feigl, E. O. (1992) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1992.262.5.h1579 · Cited by 109 · see citing works
Adaptive responses of coronary circulation and myocardium to chronic reduction in perfusion pressure and flow
Mills, I., Fallon, J. T., Wrenn, D. S., Sasken, H., Gray, W., Bier, J., LEVINE, D. J., Berman, S., Gilson, M. F., & Gewirtz, H. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.2.h447 · Cited by 109 · see citing works

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2 of the 646 references couldn’t be matched to a known paper.

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Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280 · see citing works
Coronary Microvascular Dysfunction
Crea, F., Lanza, G. A., & Camici, P. G. (2013) · Springer eBooks · doi:10.1007/978-88-470-5367-0 · Cited by 1,295 · see citing works
Regulation of increased blood flow (hyperemia) to muscles during exercise: A hierarchy of competing physiological needs
Joyner, M. J., & Casey, D. P. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2013 · Cited by 833 · see citing works
Vascular Adaptation to Exercise in Humans: Role of Hemodynamic Stimuli
Green, D. J., Hopman, M. T. E., Padilla, J., Laughlin, M. H., & Thijssen, D. H. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00014.2016 · Cited by 821 · see citing works
Exercise and the Cardiovascular System: Clinical Science and Cardiovascular Outcomes
Lavie, C. J., Arena, R., Swift, D. L., Johannsen, N. M., Sui, X., Lee, D.-C., Earnest, C. P., Church, T. S., O’Keefe, J. H., Milani, R. V., et al. (2015) · Circulation Research · doi:10.1161/circresaha.117.305205 · Cited by 782 · see citing works
Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients
Nielsen, R. R., Møller, N., Gormsen, L. C., Tolbod, L. P., Hansson, N. H., Sorensen, J., Harms, H. J., Frøkiær, J., Eiskjær, H., Jespersen, N. R., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.036459 · Cited by 521 · see citing works
Diabetic Microvascular Disease: An Endocrine Society Scientific Statement
Barrett, E. J., Liu, Z., Khamaisi, M., King, G. L., Klein, R., Klein, R., Hughes, T. M., Craft, S., Freedman, B. I., Bowden, D. W., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01922 · Cited by 519 · see citing works
Coronary microvascular dysfunction: mechanisms and functional assessment
Camici, P. G., d’Amati, G., & Rimoldi, O. E. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.160 · Cited by 500 · see citing works
Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction
Lévy, B., Clère-Jehl, R., Legras, A., Morichau-Beauchant, T., Léone, M., Ganster, F., Quenot, J., Kimmoun, A., Cariou, A., Lassus, J. P. E., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.04.051 · Cited by 477 · see citing works
Effects of Exercise to Improve Cardiovascular Health
Pinckard, K. M., Baskin, K. K., & Stanford, K. I. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00069 · Cited by 477 · see citing works
The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography
Lancellotti, P., Pellikka, P. A., Budts, W., Chaudhry, F. A., Donal, E., Dulgheru, R., Edvardsen, T., Garbi, M., Ha, J., Kane, G. C., et al. (2016) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jew190 · Cited by 443 · see citing works
Microvascular Dysfunction in Diabetes Mellitus and Cardiometabolic Disease
Horton, W. B., & Barrett, E. J. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa025 · Cited by 441 · see citing works
Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction
Severino, P., D’Amato, A., Pucci, M., Infusino, F., Adamo, F., Birtolo, L. I., Netti, L., Montefusco, G., Chimenti, C., Lavalle, C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218118 · Cited by 362 · see citing works
Reappraisal of Ischemic Heart Disease
Kaski, J. C., Crea, F., Gersh, B. J., & Camici, P. G. (2018) · Circulation · doi:10.1161/circulationaha.118.031373 · Cited by 342 · see citing works
The Clinical Use of Stress Echocardiography in Non-Ischaemic Heart Disease: Recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography
Lancellotti, P., Pellikka, P. A., Budts, W., Chaudhry, F. A., Donal, E., Dulgheru, R., Edvardsen, T., Garbi, M., Ha, J., Kane, G. C., et al. (2017) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2016.10.016 · Cited by 312 · see citing works
Cell Communications in the Heart
Tı̂rziu, D., Giordano, F. J., & Simons, M. (2010) · Circulation · doi:10.1161/circulationaha.108.847731 · Cited by 301 · see citing works
Regulation of Coronary Blood Flow
Goodwill, A. G., Dick, G. M., Kiel, A. M., & Tune, J. D. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160016 · Cited by 301 · see citing works
Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue
Saxton, S. N., Clark, B., Withers, S., Eringa, E. C., & Heagerty, A. M. (2019) · Physiological Reviews · doi:10.1152/physrev.00034.2018 · Cited by 277 · see citing works
Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms
Ellison, G. M., Waring, C. D., Vicinanza, C., & Torella, D. (2011) · Heart · doi:10.1136/heartjnl-2011-300639 · Cited by 272 · see citing works
Regulation of Coronary Blood Flow in Health and Ischemic Heart Disease
Duncker, D. J., Koller, Á., Merkus, D., & Canty, J. M. (2014) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2014.12.002 · Cited by 259 · see citing works
Self-citation
Peripheral Circulation
Laughlin, M. H., Davis, M. J., Secher, N. H., LIESHOUT, J. J. V., Arce‐Esquivel, A. A., Simmons, G. H., Bender, S. B., Padilla, J., Bache, R. J., Merkus, D., et al. (2012) · Comprehensive physiology · doi:10.1002/cphy.c100048 · Cited by 264 · see citing works
Self-citation
On the role of 4-hydroxynonenal in health and disease
Csala, M., Kardon, T., Legeza, B., Lizák, B., Mandl, J., Margittai, É., Puskás, F., Száraz, P., Szelényi, P., & Bánhegyi, G. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.01.015 · Cited by 244 · see citing works
Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study
Gormsen, L. C., Svart, M. V., Thomsen, H. H., Søndergaard, E., Vendelbo, M. H., Christensen, N. L., Tolbod, L. P., Harms, H. J., Nielsen, R. R., Wiggers, H., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005066 · Cited by 235 · see citing works
The role of Ca2+ signaling in the coordination of mitochondrial ATP production with cardiac work
Balaban, R. S. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.05.011 · Cited by 232 · see citing works
2014 Williams Harvey Lecture: importance of coronary vasomotion abnormalities--from bench to bedside
Shimokawa, H. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu427 · Cited by 231 · see citing works
Cardiovascular adenosine receptors: Expression, actions and interactions
Headrick, J. P., Ashton, K. J., Rose’Meyer, R. B., & Peart, J. N. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.06.002 · Cited by 229 · see citing works
Are There Deleterious Cardiac Effects of Acute and Chronic Endurance Exercise?
Eijsvogels, T. M. H., Fernández, A. B., & Thompson, P. D. (2015) · Physiological Reviews · doi:10.1152/physrev.00029.2014 · Cited by 229 · see citing works
Coronary vascular regulation, remodelling, and collateralization: mechanisms and clinical implications on behalf of the working group on coronary pathophysiology and microcirculation
Pries, A. R., Badimón, L., Bugiardini, R., Camici, P. G., Dorobanţu, M., Duncker, D. J., Escaned, J., Koller, Á., Piek, J. J., & de Wit, C. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv100 · Cited by 224 · see citing works
Self-citation
Modulating the Vascular Response to Limb Ischemia
Cooke, J. P., & Losordo, D. W. (2015) · Circulation Research · doi:10.1161/circresaha.115.303565 · Cited by 219 · see citing works
Metabolic Scaling in Complex Living Systems
Glazier, D. S. (2014) · Systems · doi:10.3390/systems2040451 · Cited by 202 · see citing works
Stress Myocardial Perfusion: Imaging with Multidetector CT
Rossi, A., Merkus, D., Klotz, E., Mollet, N. R., de Feyter, P. J., & Krestin, G. P. (2013) · Radiology · doi:10.1148/radiol.13112739 · Cited by 199 · see citing works
The Clinical Value of Myocardial Blood Flow Measurement
Camici, P. G., & Rimoldi, O. E. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.054478 · Cited by 196 · see citing works
Theoretical model of blood flow autoregulation: roles of myogenic, shear-dependent, and metabolic responses
Carlson, B. E., Arciero, J. C., & Secomb, T. W. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00262.2008 · Cited by 184 · see citing works
The SLC9A-C Mammalian Na + /H + Exchanger Family: Molecules, Mechanisms, and Physiology
Pedersen, S. F., & Counillon, L. (2019) · Physiological Reviews · doi:10.1152/physrev.00028.2018 · Cited by 187 · see citing works
Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics
Chen, H., Chen, C., Spanos, M., Li, G., Lü, R., Bei, Y., & Xiao, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01153-1 · Cited by 183 · see citing works
Vascular smooth muscle phenotypic diversity and function
Fisher, S. A. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00111.2010 · Cited by 178 · see citing works
Brief bouts of device-measured intermittent lifestyle physical activity and its association with major adverse cardiovascular events and mortality in people who do not exercise: A prospective cohort study
Ahmadi, M. N., Hamer, M., Gill, J. M. R., Murphy, M., Sanders, J. P., Doherty, A., & Stamatakis, E. (2023) · The Lancet Public Health · doi:10.1016/s2468-2667(23)00183-4 · Cited by 172 · see citing works
Coronary Blood Flow and Myocardial Ischemia
Weil, B. R., & Canty, J. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6705-2_22 · Cited by 165 · see citing works
Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart
Rasmussen, T. P., Wu, Y., Joiner, M.-L. A., Koval, O. M., Wilson, N. R., Luczak, E. D., Wang, Q., Chen, B., Gao, Z., Zhu, Z., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504705112 · Cited by 162 · see citing works
Understanding Key Mechanisms of Exercise-Induced Cardiac Protection to Mitigate Disease: Current Knowledge and Emerging Concepts
Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., Patterson, N. L., & McMullen, J. R. (2017) · Physiological Reviews · doi:10.1152/physrev.00043.2016 · Cited by 168 · see citing works
Exercise and Parkinson's disease
Xu, X., Fu, Z., & Le, W. (2019) · International Review of Neurobiology · doi:10.1016/bs.irn.2019.06.003 · Cited by 158 · see citing works
Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO
Segers, V. F. M., Brutsaert, D. L., & Keulenaer, G. W. D. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00382 · Cited by 154 · see citing works
Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA)
Cenko, E., Badimón, L., Bugiardini, R., Claeys, M. J., Luca, G. D., de Wit, C., Dérumeaux, G., Dorobanţu, M., Duncker, D. J., Eringa, E. C., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab298 · Cited by 151 · see citing works
Self-citation
The coronary circulation in exercise training
Laughlin, M. H., Bowles, D. K., & Duncker, D. J. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00574.2011 · Cited by 150 · see citing works
Self-citation
Fractional flow reserve as a surrogate for inducible myocardial ischaemia
van de Hoef, T. P., Meuwissen, M., Escaned, J., Davies, J. E., Siebes, M., Spaan, J. A. E., & Piek, J. J. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.86 · Cited by 144 · see citing works
Biochemical Underpinnings of Immune Cell Metabolic Phenotypes
Olenchock, B. A., Rathmell, J. C., & Heiden, M. G. V. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.013 · Cited by 136 · see citing works
Adenosine and its receptors in the heart: Regulation, retaliation and adaptation
Headrick, J. P., Peart, J. N., Reichelt, M. E., & Haseler, L. J. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.11.016 · Cited by 134 · see citing works
Developmental toxicity and cardiac effects of butyl benzyl phthalate in zebrafish embryos
Sun, G., & Liu, K. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.09.020 · Cited by 124 · see citing works
Optimization of high intensity interval exercise in coronary heart disease
Guiraud, T., Juneau, M., Nigam, A., Gayda, M., Meyer, P., Mekary, S., Paillard, F., & Bosquet, L. (2009) · European Journal of Applied Physiology · doi:10.1007/s00421-009-1287-z · Cited by 123 · see citing works
Inflammation in Coronary Microvascular Dysfunction
Sagris, M., Theofilis, P., Antonopoulos, A. S., Oikonomou, E., Paschaliori, C., Galiatsatos, N., Tsioufis, K., & Tousoulis, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413471 · Cited by 115 · see citing works
Benefits of Exercise Training on Coronary Blood Flow in Coronary Artery Disease Patients
Bruning, R. S., & Sturek, M. S. (2014) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2014.10.006 · Cited by 114 · see citing works
The effects of acute and chronic exercise on the vasculature
Whyte, J. J., & Laughlin, M. H. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02127.x · Cited by 114 · see citing works
Adenosine and maximum coronary vasodilation in humans: myth and misconceptions in the assessment of coronary reserve
Heusch, G. (2009) · Basic Research in Cardiology · doi:10.1007/s00395-009-0074-7 · Cited by 113 · see citing works
MR Myocardial Perfusion Imaging
Coelho‐Filho, O. R., Rickers, C., Kwong, R. Y. K., & Jerosch‐Herold, M. (2013) · Radiology · doi:10.1148/radiol.12110918 · Cited by 112 · see citing works
Heterogeneity and Variability in Pressure Autoregulation of Organ Blood Flow: Lessons Learned Over 100+ Years
Meng, L., Wang, Y., Zhang, L., & McDonagh, D. L. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003569 · Cited by 112 · see citing works
Exercise and the right ventricle: a potential Achilles’ heel
Gerche, A. L., Rakhit, D. J., & Claessen, G. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx156 · Cited by 111 · see citing works
Anatomy and physiology of coronary blood flow
Schelbert, H. R. (2010) · Journal of Nuclear Cardiology · doi:10.1007/s12350-010-9255-x · Cited by 108 · see citing works
Can Exercise Teach Us How to Treat Heart Disease?
Mann, N., & Rosenzweig, A. (2012) · Circulation · doi:10.1161/circulationaha.111.060376 · Cited by 105 · see citing works
Role of potassium channels in coronary vasodilation
Dick, G. M., & Tune, J. D. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2009.009201 · Cited by 101 · see citing works
Production of reactive oxygen species in endothelial cells under different pulsatile shear stresses and glucose concentrations
Chin, L. K., Yu, J. Q., Fu, Y. H., Yu, T., Liu, A. Q., & Luo, K. Q. (2011) · Lab on a Chip · doi:10.1039/c0lc00651c · Cited by 98 · see citing works
Repeatability of Fractional Flow Reserve Despite Variations in Systemic and Coronary Hemodynamics
Johnson, N. P., Johnson, D. T., Kirkeeide, R. L., Berry, C., Bruyne, B. D., Fearon, W. F., Oldroyd, K. G., Pijls, N. H. J., & Gould, K. L. (2015) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2015.01.039 · Cited by 96 · see citing works
Local control of skeletal muscle blood flow during exercise: influence of available oxygen
Casey, D. P., & Joyner, M. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00895.2011 · Cited by 96 · see citing works
Coronary Artery Dimensions in Febrile Children Without Kawasaki Disease
Muniz, J. C., Dummer, K., Gauvreau, K., Colan, S. D., Fulton, D. R., & Newburger, J. W. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.112.000159 · Cited by 95 · see citing works
Imaging Microvascular Dysfunction and Mechanisms for Female-Male Differences in CAD
Patel, M., Bui, L., Kirkeeide, R. L., & Gould, K. L. (2016) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2016.02.003 · Cited by 94 · see citing works
Ten questions about systems biology
Joyner, M. J., & Pedersen, B. K. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.201509 · Cited by 93 · see citing works
State of Shock: Contemporary Vasopressor and Inotrope Use in Cardiogenic Shock
Bloom, J. E., Chan, W., Kaye, D. M., & Stub, D. A. (2023) · Journal of the American Heart Association · doi:10.1161/jaha.123.029787 · Cited by 93 · see citing works
Macrolides induce severe cardiotoxicity and developmental toxicity in zebrafish embryos
Yan, Z., Huang, X., Xie, Y., Song, M., Zhu, K., & Ding, S. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.07.432 · Cited by 90 · see citing works
Contribution of oxygen extraction fraction to maximal oxygen uptake in healthy young men
Skattebo, Ø., Calbet, J. A. L., Rud, B., Capelli, C., & Hallén, J. (2020) · Acta Physiologica · doi:10.1111/apha.13486 · Cited by 90 · see citing works
Acute Responses to High-Intensity Intermittent Exercise in CHD Patients
Guiraud, T., Nigam, A., Juneau, M., MEYER, P., Gayda, M., & Bosquet, L. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181ebc5de · Cited by 88 · see citing works
Peritoneal Dialysis is not Associated with Myocardial Stunning
Selby, N. M., & McIntyre, C. W. (2010) · Peritoneal Dialysis International · doi:10.3747/pdi.2010.00007 · Cited by 88 · see citing works
Central and peripheral hemodynamics in exercising humans: leg vs arm exercise
Calbet, J. A. L., González‐Alonso, J., Helge, J. W., Søndergaard, H., Munch‐Andersen, T., Saltin, B., & Boushel, R. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12604 · Cited by 86 · see citing works
Targeting the dominant mechanism of coronary microvascular dysfunction with intracoronary physiology tests
Mejía-Rentería, H. D., van der Hoeven, N., van de Hoef, T. P., Heemelaar, J. C., Ryan, N., Lerman, A., van Royen, N., & Escaned, J. (2017) · International journal of cardiac imaging · doi:10.1007/s10554-017-1136-9 · Cited by 83 · see citing works
Energy metabolism design of the striated muscle cell
Glancy, B. C., & Balaban, R. S. (2021) · Physiological Reviews · doi:10.1152/physrev.00040.2020 · Cited by 83 · see citing works
Risk assessment of energy drinks with focus on cardiovascular parameters and energy drink consumption in Europe
Ehlers, A., Marakis, G. N., Lampen, A., & Hirsch‐Ernst, K. I. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.05.028 · Cited by 82 · see citing works
Experimental animal models of coronary microvascular dysfunction
Sorop, O., van de Wouw, J., Chandler, S., Ohanyan, V. A., Tune, J. D., Chilian, W. M., Merkus, D., Bender, S. B., & Duncker, D. J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa002 · Cited by 81 · see citing works
Self-citation
Domestication of the cardiac mitochondrion for energy conversion
Balaban, R. S. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.02.018 · Cited by 81 · see citing works
Heart Rate and Heart Failure With Preserved Ejection Fraction
Meyer, M., & LeWinter, M. M. (2019) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006213 · Cited by 81 · see citing works
Hypertension and coronary artery disease: epidemiology, physiology, effects of treatment, and recommendations
Weber, T., Lang, I. M., Zweiker, R., Horn, S., Wenzel, R. R., Watschinger, B., Slany, J., Eber, B., Roithinger, F. X., & Metzler, B. (2016) · Wiener klinische Wochenschrift · doi:10.1007/s00508-016-0998-5 · Cited by 78 · see citing works
Normal values of thermodilution-derived absolute coronary blood flow and microvascular resistance in humans
Fournier, S., Keulards, D. C. J., Veer, M. V. ’., Colaiori, I., Gioia, G. D., Zimmermann, F. M., Mizukami, T., Nagumo, S., Kodeboina, M., Farissi, M. E., et al. (2021) · EuroIntervention · doi:10.4244/eij-d-20-00684 · Cited by 78 · see citing works
Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease
Fedele, F., Mancone, M., Chilian, W. M., Severino, P., Canali, E., Logan, S. J., Marchis, M. L. D., Volterrani, M., Palmirotta, R., & Guadagni, F. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0387-4 · Cited by 78 · see citing works
Comparative cardiovascular physiology: future trends, opportunities and challenges
Burggren, W. W., Christoffels, V. M., Crossley, D. A., Enok, S., Farrell, A. P., Hedrick, M. S., Hicks, J. W., Jensen, B. K., Moorman, A. F. M., Mueller, C. A., et al. (2013) · Acta Physiologica · doi:10.1111/apha.12170 · Cited by 78 · see citing works
Relative Myocardial Blood Flow by Dynamic Computed Tomographic Perfusion Imaging Predicts Hemodynamic Significance of Coronary Stenosis Better Than Absolute Blood Flow
Kono, A. K., Coenen, A., Lubbers, M. M., Kurata, A., Rossi, A., Dharampal, A. S., Dijkshoorn, M. L., van Geuns, R., Krestin, G. P., & Nieman, K. (2014) · Investigative Radiology · doi:10.1097/rli.0000000000000087 · Cited by 77 · see citing works
Heart of the matter: Coronary dysfunction in metabolic syndrome
Berwick, Z. C., Dick, G. M., & Tune, J. D. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.06.025 · Cited by 76 · see citing works
Theoretical models for coronary vascular biomechanics: Progress & challenges
Waters, S. L., Alastruey, J., Beard, D. A., Bovendeerd, P. H. M., Davies, P. F., Jayaraman, G., Jensen, O. E., Lee, J., Parker, K. H., Popel, A. S., et al. (2010) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2010.10.001 · Cited by 77 · see citing works
Saline-Induced Coronary Hyperemia
Bruyne, B. D., Adjedj, J., Xaplanteris, P., Ferrara, A., Mo, Y., Pěnička, M., Floré, V., Pellicano, M., Tóth, G. G., Barbato, E., et al. (2017) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.116.004719 · Cited by 77 · see citing works
Self-citation
The Contribution of Individual Exercise Training Components to Clinical Outcomes in Randomised Controlled Trials of Cardiac Rehabilitation: A Systematic Review and Meta-regression
Abell, B., Glasziou, P., & Hoffmann, T. (2017) · Sports Medicine - Open · doi:10.1186/s40798-017-0086-z · Cited by 82 · see citing works
Treatment of Angina: Where Are We?
Balla, C., Pavasini, R., & Ferrari, R. (2018) · Cardiology · doi:10.1159/000487936 · Cited by 77 · see citing works
Coronary Microcirculation in Aortic Stenosis
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Katz, P. S., Trask, A. J., Souza‐Smith, F. M., Hutchinson, K. R., Galantowicz, M. L., Lord, K. C., Stewart, J. A., Cismowski, M. J., Varner, K. J., & Lucchesi, P. A. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0201-0 · Cited by 73 · see citing works
Evaluation of Optimal Diastolic Blood Pressure Range Among Adults With Treated Systolic Blood Pressure Less Than 130 mm Hg
Li, J., Somers, V. K., Gao, X., Chen, Z., Ju, J., Lin, Q., Mohamed, E. A., Karim, S., Xu, H. F., & Zhang, L. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.37554 · Cited by 72 · see citing works
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Campos, J. C., Gomes, M. K., & Ferreira, J. C. B. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.08.035 · Cited by 70 · see citing works
Increased basal coronary blood flow as a cause of reduced coronary flow reserve in diabetic patients
Picchi, A., Limbruno, U., Focardi, M., Cortese, B., Micheli, A., Boschi, L., Severi, S., & Caterina, R. D. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00615.2011 · Cited by 70 · see citing works
The effects of cold and exercise on the cardiovascular system
Manou‐Stathopoulou, V., Goodwin, C. D., Patterson, T., Redwood, S. R., Marber, M. S., & Williams, R. (2015) · Heart · doi:10.1136/heartjnl-2014-306276 · Cited by 70 · see citing works
The role of capillary transit time heterogeneity in myocardial oxygenation and ischemic heart disease
Østergaard, L., Kristiansen, S. B., Angleys, H., Frøkiær, J., Hasenkam, J. M., Jespersen, S. N., & Bøtker, H. E. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0409-x · Cited by 70 · see citing works
Physiology in Medicine: Peripheral arterial disease
Muller, M. D., Reed, A. B., Leuenberger, U. A., & Sinoway, L. I. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00885.2013 · Cited by 69 · see citing works
Autoregulation of Coronary Blood Supply in Response to Demand
Johnson, N. P., Gould, K. L., & Bruyne, B. D. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.03.293 · Cited by 68 · see citing works
Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia
Morales‐Cano, D., Moreno, L., Barreira, B., Pandolfi, R., Chamorro, V., Jiménez, R., Villamor, E., Duarte, J., Pérez‐Vizcaíno, F., & Cogolludo, A. L. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv020 · Cited by 68 · see citing works
Multiplexed Temporal Quantification of the Exercise-regulated Plasma Peptidome
Parker, B. L., Burchfield, J. G., Clayton, D., Geddes, T. A., Payne, R. J., Kiens, B., Wojtaszewski, J. F. P., Richter, E. A., & James, D. E. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra117.000020 · Cited by 65 · see citing works
Extreme Heat and Cardiovascular Health: What a Cardiovascular Health Professional Should Know
Chaseling, G. K., Iglesies‐Grau, J., Juneau, M., Nigam, A., Kaiser, D., & Gagnon, D. (2021) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2021.08.008 · Cited by 67 · see citing works
Altered Mechanism of Adenosine-Induced Coronary Arteriolar Dilation in Early-Stage Metabolic Syndrome
Bender, S. B., Tune, J. D., Borbouse, L., Long, X., Sturek, M. S., & Laughlin, M. H. (2009) · Experimental Biology and Medicine · doi:10.3181/0812-rm-350 · Cited by 65 · see citing works

Regulation of coronary resistance vessel tone in response to exercise.
Duncker, D. J., Bache, R. J., & Merkus, D. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.10.007 · Cited by 59 · see citing works
Self-citation
Acute Adaptations of the Coronary Circulation to Exercise
Duncker, D. J., & Merkus, D. (2005) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:43:1:017 · Cited by 32 · see citing works
Self-citation
Control of Blood Flow to Cardiac and Skeletal Muscle During Exercise
Laughlin, M. H., Korthuis, R. J., Duncker, D. J., & Bache, R. J. (1995) · Comprehensive physiology · doi:10.1002/j.2040-4603.1995.tb01713.x
Self-citation
The coronary circulation in exercise training
Laughlin, M. H., Bowles, D. K., & Duncker, D. J. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00574.2011 · Cited by 150 · see citing works
Self-citation
Cardiovascular Physiology of Exercise
Dowell, R. T. (1983) · Exercise Medicine · doi:10.1016/b978-0-12-119720-9.50008-0 · Cited by 3 · see citing works

Authors: Duncker, D. J., & Bache, R. J.
Affiliations: Erasmus MC (NL)
ORCID: Duncker, Dirk J.
Bache, Robert J.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2008-07
Volume: 88
Issue: 3
Pages: 1009-1086
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00045.2006
OpenAlex: W2134256354
Cited by: 936
References: 646
Citations by year: 2026: 44 · 2025: 49 · 2024: 50 · 2023: 53 · 2022: 55 · 2021: 69 · 2020: 40 · 2019: 45 · 2018: 57 · 2017: 61 · 2016: 36 · 2015: 50 · 2014: 48 · 2013: 66 · 2012: 60
FWCI: 8.93
Type: journal article
Language: en
Open access: closed
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: coronary blood flow, physical activity, myocardial oxygen demand, coronary vasodilation, coronary microcirculation, exercise training, capillary density, adrenergic tone, nitric oxide synthase, endothelium-dependent vasodilation, myogenic tone, protein kinase C, nitric oxide, cardiac output, coronary vascular resistance
MeSH terms: Adaptation, Physiological, Animals, Collateral Circulation, Coronary Circulation, Hemodynamics, Humans, Models, Cardiovascular, Oxygen Consumption, Exercise, Ventricular Function, Coronary Stenosis

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Regulation of coronary blood flow during exercise

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