The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle
Abstract
Vasodilators are used clinically for the treatment of hypertension and heart failure. The effects of some vasodilators seem to be mediated by membrane hyperpolarization. The molecular basis of this hyperpolarization has been investigated by examining the properties of single K + channels in arterial smooth muscle cells. The presence of adenosine triphosphate (ATP)-sensitive K + channels in these cells was demonstrated at the single channel level. These channels were opened by the hyperpolarizing vasodilator cromakalim and inhibited by the ATP-sensitive K + channel blocker glibenclamide. Furthermore, in arterial rings the vasorelaxing actions of the drugs diazoxide, cromakalim, and pinacidil and the hyperpolarizing actions of vasoactive intestinal polypeptide and acetylcholine were blocked by inhibitors of the ATP-sensitive K + channel, suggesting that all these agents may act through a common pathway in smooth muscle by opening ATP-sensitive K + channels.
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Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Inagaki, N., Gonoi, T., Iv, J. P. C., Wang, C.-Z., Aguilar-Bryan, L., Bryan, J., & Seino, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80124-5 · Cited by 974
Regulation of coronary blood flow during exercise
Duncker, D. J., & Bache, R. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00045.2006 · Cited by 936
Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels
Daut, J., Maier-Rudolph, W., von Beckerath, N., Mehrke, G., Günther, K., & Goedel-Meinen, L. (1990) · Science · doi:10.1126/science.2107575 · Cited by 593
A Novel Sulfonylurea Receptor Forms with BIR (Kir6.2) a Smooth Muscle Type ATP-sensitive K+ Channel
Isomoto, S., Kondo, C., Yamada, M., Matsumoto, S., Higashiguchi, O., Horio, Y., Matsuzawa, Y., & Kurachi, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24321 · Cited by 544
Metadata
- Authors
- Standen, N. B., Quayle, J. M., Davies, N. W., Brayden, J. E., Huang, Y., & Nelson, M. T.
- Venue
- Science
- Published
- 1989-07-14
- Volume
- 245
- Issue
- 4914
- Pages
- 177-180
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990845205
- Cited by
- 1,190
- References
- 1
- FWCI
- 28.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Standen, N. B., Quayle, J. M., Davies, N. W., Brayden, J. E., Huang, Y., & Nelson, M. T. (1989). Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle. Science. https://doi.org/10.1126/science.2501869
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