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The Minimal Number of Class II MHC-Antigen Complexes Needed for T Cell Activation
Abstract
Major histocompatibility complex (MHC) molecules are exposed to large quantities of self and nonself antigens. It is not known what fraction of MHC molecules needs to be occupied by antigen to induce a T cell response. A quantitative study of naturally processed antigen indicated that T cells could be activated when only 0.03 percent of the total I-E d purified from antigen-presenting cells (APCs) was occupied with antigen. B cells and macrophages processed hen egg lysozyme (HEL) with different efficiencies, but similar degrees of occupancy were required for T cell stimulation. Higher occupancy was needed for I-E d -transfected L cells, possibly reflecting the requirement for other accessory molecules for efficient APC-T cell interaction.
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Cited by
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129
Porgador, A., Yewdell, J. W., Deng, Y., Bennink, J. R., & Germain, R. N. (1997) · Immunity · doi:10.1016/s1074-7613(00)80447-1 · Cited by 669
CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
van der Merwe, P. A., Bodian, D. L., Daenke, S., Linsley, P., & Davis, S. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.393 · Cited by 551
Valitutti, S., Müller, S., Dessing, M., & Lanzavecchia, A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.4.1917 · Cited by 435
SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19
Grifoni, A., Sidney, J., Vita, R., Peters, B., Crotty, S., Weiskopf, D., & Sette, A. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.05.010 · Cited by 314
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Metadata
- Authors
- Demotz, S., Grey, H. M., & Sette, A.
- Venue
- Science
- Published
- 1990-08-31
- Volume
- 249
- Issue
- 4972
- Pages
- 1028-1030
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999436383
- Cited by
- 400
- References
- 0
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- closed
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