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Induction by Antigen of Intrathymic Apoptosis of CD4 + CD8 + TCR lo Thymocytes in Vivo
Abstract
In order to examine the mechanisms by which clonal deletion of autoreactive T cells occurs, a peptide antigen was used to induce deletion of antigen-reactive thymocytes in vivo. Mice transgenic for a T cell receptor (TCR) that reacts to this peptide contain thymocytes that progress from the immature to the mature phenotype. Intraperitoneal administration of the peptide antigen to transgenic mice results in a rapid deletion of the immature CD4 + CD8 + TCR lo thymocytes. Apoptosis of cortical thymocytes can be seen within 20 hours of treatment. These results provide direct evidence for the in vivo role of apoptosis in the development of antigen-induced tolerance.
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Cited by
Harrington, L. E., Hatton, R. D., Mangan, P. R., Turner, H., Murphy, T. L., Murphy, K. M., & Weaver, C. T. (2005) · Nature Immunology · doi:10.1038/ni1254 · Cited by 4,742
Self-citationDevelopment of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134
Self-citationPositive and negative selection of T cells
Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141107 · Cited by 1,601
Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node
Miller, M. J., Wei, S. H., Parker, I., & Cahalan, M. D. (2002) · Science · doi:10.1126/science.1070051 · Cited by 1,207
Boonstra, A., Barrat, F. J., Crain, C., Heath, V. L., Savelkoul, H. F. J., & O’Garra, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.4974 · Cited by 1,123
Metadata
- Authors
- Murphy, K. M., Heimberger, A. B., & Loh, D. Y.
- Venue
- Science
- Published
- 1990-12-21
- Volume
- 250
- Issue
- 4988
- Pages
- 1720-1723
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2045008512
- Cited by
- 1,735
- References
- 0
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Induction by Antigen of Intrathymic Apoptosis of CD4 + CD8 + TCR lo Thymocytes in Vivo. https://app.cochat.ai/papers/10.1126/science.2125367
- The paper
- Murphy, K. M., Heimberger, A. B., & Loh, D. Y. (1990). Induction by Antigen of Intrathymic Apoptosis of CD4 + CD8 + TCR lo Thymocytes in Vivo. Science. https://doi.org/10.1126/science.2125367
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
