The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular Characterization of a Functional cDNA Encoding the Rat Substance P Receptor
Abstract
Substance P is a member of the tachykinin peptide family and participates in the regulation of diverse biological processes. The polymerase chain reaction and conventional library screening were used to isolate a complementary DNA (cDNA) encoding the rat substance P receptor from brain and submandibular gland. By homology analysis, this receptor belongs to the G protein-coupled receptor superfamily. The receptor cDNA was expressed in a mammalian cell line and the ligand binding properties of the encoded receptor were pharmacologically defined by Scatchard analysis and tachykinin peptide displacement as those of a substance P receptor. The distribution of the messenger RNA for this receptor is highest in urinary bladder, submandibular gland, striatum, and spinal cord, which is consistent with the known distribution of substance P receptor binding sites. Thus, this receptor appears to mediate the primary actions of substance P in various brain regions and peripheral tissues.
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Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
Cited by
Peptidomimetics for Receptor Ligands—Discovery, Development, and Medical Perspectives
Giannis, A., & Kolter, T. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199312441 · Cited by 784
Savarese, T. M., & Fraser, C. M. (1992) · Biochemical Journal · doi:10.1042/bj2830001 · Cited by 473
Ji, R.-R., Befort, K., Brenner, G. J., & Woolf, C. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00478.2002 · Cited by 461
Helke, C. J., Krause, J. E., Mantyh, P. W., Couture, R., & Rannon, M. J. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.6.1969374 · Cited by 444
Self-citationNakaya, Y., Kaneko, T., Shigemoto, R., Nakanishi, S., & Mizuno, N. (1994) · Journal of Comparative Neurology · doi:10.1002/cne.903470208 · Cited by 408
Metadata
- Authors
- Hershey, A. D., & Krause, J. E.
- Venue
- Science
- Published
- 1990-02-23
- Volume
- 247
- Issue
- 4945
- Pages
- 958-962
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2128020612
- Cited by
- 345
- References
- 1
- FWCI
- 16.97
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
