The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
ERK MAP Kinase Activation in Superficial Spinal Cord Neurons Induces Prodynorphin and NK-1 Upregulation and Contributes to Persistent Inflammatory Pain Hypersensitivity
Open accessAbstract
Activation of ERK (extracellular signal-regulated kinase) MAP (mitogen-activated protein) kinase in dorsal horn neurons of the spinal cord by peripheral noxious stimulation contributes to short-term pain hypersensitivity. We investigated ERK activation by peripheral inflammation and its involvement in regulating gene expression in the spinal cord and in contributing to inflammatory pain hypersensitivity. Injection of complete Freund's adjuvant (CFA) into a hindpaw produced a persistent inflammation and a sustained ERK activation in neurons in the superficial layers (laminae I-IIo) of the dorsal horn. CFA also induced an upregulation of prodynorphin and neurokinin-1 (NK-1) in dorsal horn neurons, which was suppressed by intrathecal delivery of the MEK (MAP kinase kinase) inhibitor U0126. CFA-induced phospho-ERK primarily colocalized with prodynorphin and NK-1 in superficial dorsal horn neurons. Although intrathecal injection of U0126 did not affect basal pain sensitivity, it did attenuate both the establishment and maintenance of persistent inflammatory heat and mechanical hypersensitivity. Activation of the ERK pathway in a subset of nociceptive spinal neurons contributes, therefore, to persistent pain hypersensitivity, possibly via transcriptional regulation of genes, such as prodynorphin and NK-1.
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Citations
Cites
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Cited by
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630
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Self-citationJin, S.-X., Zhuang, Z.-Y., Woolf, C. J., & Ji, R.-R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-10-04017.2003 · Cited by 853
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Metadata
- Authors
- Ji, R.-R., Befort, K., Brenner, G. J., & Woolf, C. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-01-15
- Volume
- 22
- Issue
- 2
- Pages
- 478-485
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1919059205
- Cited by
- 461
- References
- 60
- FWCI
- 14.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ji, R.-R., Befort, K., Brenner, G. J., & Woolf, C. J. (2002). ERK MAP Kinase Activation in Superficial Spinal Cord Neurons Induces Prodynorphin and NK-1 Upregulation and Contributes to Persistent Inflammatory Pain Hypersensitivity. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-02-00478.2002
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