The DOI matches its Crossref record.
Induction of AIDS in Rhesus Monkeys by Molecularly Cloned Simian Immunodeficiency Virus
Abstract
Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.
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Citations
Cited by
Specific incorporation of cyclophilin A into HIV-1 virions
Franke, E. K., Yuan, H. E. H., & Luban, J. (1994) · Nature · doi:10.1038/372359a0 · Cited by 745
Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1935 · Cited by 675
Species-Specific Activity of SIV Nef and HIV-1 Vpu in Overcoming Restriction by Tetherin/BST2
Jia, B., Serra-Moreno, R., Neidermyer, W., Rahmberg, A., Mackey, J., Fofana, I. B., Johnson, W. E., Westmoreland, S., & Evans, D. T. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000429 · Cited by 406
Re, F., Braaten, D., Franke, E. K., & Luban, J. (1995) · Journal of Virology · doi:10.1128/jvi.69.11.6859-6864.1995 · Cited by 375
Animal models for HIV/AIDS research
Hatziioannou, T., & Evans, D. T. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2911 · Cited by 340
Metadata
- Authors
- Kestler, H., Kodama, T., Ringler, D., Marthas, M., Pedersen, N., Lackner, A., Regier, D., Sehgal, P., Daniel, M., King, N., & Desrosiers, R.
- Venue
- Science
- Published
- 1990-06
- Volume
- 248
- Issue
- 4959
- Pages
- 1109-1112
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078069915
- Cited by
- 514
- References
- 0
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Induction of AIDS in Rhesus Monkeys by Molecularly Cloned Simian Immunodeficiency Virus. https://app.cochat.ai/papers/10.1126/science.2160735
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- Kestler, H., Kodama, T., Ringler, D., Marthas, M., Pedersen, N., Lackner, A., Regier, D., Sehgal, P., Daniel, M., King, N., & Desrosiers, R. (1990). Induction of AIDS in Rhesus Monkeys by Molecularly Cloned Simian Immunodeficiency Virus. Science. https://doi.org/10.1126/science.2160735
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
