The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.
Animal models for HIV/AIDS research
Open accessAbstract
The AIDS pandemic continues to present us with unique scientific and public health challenges. Although the development of effective antiretroviral therapy has been a major triumph, the emergence of drug resistance requires active management of treatment regimens and the continued development of new antiretroviral drugs. Moreover, despite nearly 30 years of intensive investigation, we still lack the basic scientific knowledge necessary to produce a safe and effective vaccine against HIV-1. Animal models offer obvious advantages in the study of HIV/AIDS, allowing for a more invasive investigation of the disease and for preclinical testing of drugs and vaccines. Advances in humanized mouse models, non-human primate immunogenetics and recombinant challenge viruses have greatly increased the number and sophistication of available mouse and simian models. Understanding the advantages and limitations of each of these models is essential for the design of animal studies to guide the development of vaccines and antiretroviral therapies for the prevention and treatment of HIV-1 infection.
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Cited by
Genetically engineered pigs as models for human disease
Perleberg, C., Kind, A., & Schnieke, A. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.030783 · Cited by 222
Poor Translatability of Biomedical Research Using Animals — A Narrative Review
Marshall, L. J., Bailey, J., Cassotta, M., Herrmann, K., & Pistollato, F. (2023) · Alternatives to Laboratory Animals · doi:10.1177/02611929231157756 · Cited by 219
Imle, A., Kumberger, P., Schnellbächer, N. D., Fehr, J., Carrillo-Bustamante, P., Ales, J., Schmidt, P., Ritter, C., Godinez, W. J., Müller, B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09879-3 · Cited by 76
Metadata
- Authors
- Hatziioannou, T., & Evans, D. T.
- Venue
- Nature Reviews Microbiology
- Published
- 2012-11-16
- Volume
- 10
- Issue
- 12
- Pages
- 852-867
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1974096769
- Cited by
- 340
- References
- 171
- FWCI
- 2.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
