The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation
Abstract
The progesterone receptor (PR) in the chicken oviduct is a phosphoprotein that regulates gene transcription in the presence of progesterone. Treatment with progesterone in vivo stimulates phosphorylation of the progesterone receptor. With transient transfection assays, the present work has tested whether phosphorylation participates in the regulation of PR-mediated transcription. Treatment with 8-bromo-cyclic adenosine monophosphate (8-Br cAMP), a stimulator of cAMP-dependent protein kinase [protein kinase A (PKA)], mimicked progesterone-dependent, receptor-mediated transcription in the absence of progesterone. Inhibition of PKA blocked hormone action. Treatment with okadaic acid, an inhibitor of protein phosphatases 1 and 2A, stimulated transcription in a manner similar to that of progesterone. These observations suggest that phosphorylation of the PR or other proteins in the transcription complex can modulate PR-mediated transcription in vivo.
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Citations
Cites
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383
Cited by
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383
Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
Oñate, S. A., Tsai, S. Y., Tsai, M.-J., & O'Malley, B. W. (1995) · Science · doi:10.1126/science.270.5240.1354 · Cited by 2,387
Self-citationSteroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791
Schoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216
Romero, R., Nicolaides, K., Conde-Agudelo, A., Tabor, A., O'Brien, J. M., Cetingoz, E., Da Fonseca, E., Creasy, G. W., Klein, K., Rode, L., et al. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.12.003 · Cited by 580
Metadata
- Authors
- Denner, L. A., Weigel, N. L., Maxwell, B. L., Schrader, W. T., & O'Malley, B. W.
- Venue
- Science
- Published
- 1990-12-21
- Volume
- 250
- Issue
- 4988
- Pages
- 1740-1743
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058354524
- Cited by
- 357
- References
- 1
- FWCI
- 19.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Denner, L. A., Weigel, N. L., Maxwell, B. L., Schrader, W. T., & O'Malley, B. W. (1990). Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation. Science. https://doi.org/10.1126/science.2176746
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
