The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation
Abstract
The oxyR gene positively regulates genes induced by oxidative stress in Salmonella typhimurium and Escherichia coli . Purification of the OxyR protein showed that oxidized but not reduced OxyR activates transcription of oxidative stress-inducible genes in vitro. Conversion between the two forms of OxyR is rapid and reversible. Both the oxidized and the reduced forms of the OxyR protein are capable of binding to three diverse sequences upstream of OxyR-regulated promoters, but the interactions of the two forms of OxyR with the promoter regions are different. The results suggest that direct oxidation of the OxyR protein brings about a conformational change by which OxyR transduces an oxidative stress signal to RNA polymerase.
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Cites
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Self-citationProoxidant States and Tumor Promotion
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Self-citationHow eukaryotic transcriptional activators work
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Cited by
Free Radicals in the Physiological Control of Cell Function
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Function and Activation of NF-kappaB in the Immune System
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Reconciling the chemistry and biology of reactive oxygen species
Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504
Strategies of antioxidant defense
SIES, H. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18025.x · Cited by 1,976
Redox signaling: Nitrosylation and related target interactions of nitric oxide
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Metadata
- Authors
- Storz, G., Tartaglia, L. A., & Ames, B. N.
- Venue
- Science
- Published
- 1990-04-13
- Volume
- 248
- Issue
- 4952
- Pages
- 189-194
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2064000861
- Cited by
- 874
- References
- 45
- FWCI
- 40.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Storz, G., Tartaglia, L. A., & Ames, B. N. (1990). Transcriptional Regulator of Oxidative Stress-Inducible Genes: Direct Activation by Oxidation. Science. https://doi.org/10.1126/science.2183352
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
