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Structural Characterization of a Partly Folded Apomyoglobin Intermediate
Abstract
To understand why proteins adopt particular three-dimensional structures, it is important to elucidate the hierarchy of interactions that stabilize the native state. Proteins in partly folded states can be used to dissect protein organizational hierarchies. A partly folded apomyoglobin intermediate has now been characterized structurally by trapping slowly exchanging peptide NH protons and analyzing them by two-dimensional 1 H-NMR (nuclear magnetic resonance). Protons in the A, G, and H helix regions are protected from exchange, while protons in the B and E helix regions exchange freely. On the basis of these results and the three-dimensional structure of native myoglobin, a structural model is presented for the partly folded intermediate in which a compact subdomain retains structure while the remainder of the protein is essentially unfolded.
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Cited by
Principles of protein folding — A perspective from simple exact models
Dill, K. A., Bromberg, S., Yue, K., Chan, H. S., Fiebig, K. M., Yee, D. P., & Thomas, P. D. (1995) · Protein Science · doi:10.1002/pro.5560040401 · Cited by 1,525
The folding of hen lysozyme involves partially structured intermediates and multiple pathways
Radford, S. E., Dobson, C. M., & Evans, P. A. (1992) · Nature · doi:10.1038/358302a0 · Cited by 708
Bernadó, P., Blanchard, L., Timmins, P., Marion, D., Ruigrok, R. W. H., & Blackledge, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506202102 · Cited by 441
The structural aspects of limited proteolysis of native proteins
Hubbard, S. J. (1998) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(97)00175-1 · Cited by 406
Distinct β-sheet structure in protein aggregates determined by ATR-FTIR spectroscopy
Shivu, B., Seshadri, S., Li, J., Oberg, K. A., Uversky, V. N., & Fink, A. L. (2013) · Biochemistry · doi:10.1021/bi400625v · Cited by 289
Metadata
- Authors
- Hughson, F. M., Wright, P. E., & Baldwin, R. L.
- Venue
- Science
- Published
- 1990-09-28
- Volume
- 249
- Issue
- 4976
- Pages
- 1544-1548
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975495422
- Cited by
- 705
- References
- 0
- FWCI
- 13.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hughson, F. M., Wright, P. E., & Baldwin, R. L. (1990). Structural Characterization of a Partly Folded Apomyoglobin Intermediate. Science. https://doi.org/10.1126/science.2218495
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