The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1αAntisense Oligomer
Abstract
The proliferative potential of human diploid endothelial cells is finite, and cellular senescence in vitro is accompanied by the failure of the endothelial cell to respond to exogenous growth factors. Senescent human endothelial cells were shown to contain high amounts of the transcript for the cytokine interleukin-1α (IL-1α), a potent inhibitor of endothelial cell proliferation in vitro. In contrast, transformed human endothelial cells did not contain detectable IL-1α messenger RNA. Treatment of human endothelial cell populations with an antisense oligodeoxynucleotide to the human IL-1α transcript prevented cell senescence and extended the proliferative lifespan of the cells in vitro. Removal of the IL-1α antisense oligomer resulted in the generation of the senescent phenotype and loss of proliferative potential. These data suggest that human endothelial cell senescence in vitro is a dynamic process regulated by the potential intracellular activity of IL-1α.
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Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor
Hannum, C. H., Wilcox, C. J., Arend, W. P., Joslin, F. G., Dripps, D. J., Heimdal, P. L., Armes, L. G., Sommer, A., Eisenberg, S. P., & Thompson, R. C. (1990) · Nature · doi:10.1038/343336a0 · Cited by 1,122
Cited by
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology
Arend, W. P., Malyak, M., Guthridge, C. J., & Gabay, C. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.27 · Cited by 1,071
Carriere, V., Roussel, L., Ortega, N., Lacorre, D.-A., Americh, L., Aguilar, L., Bouche, G., & Girard, J.-P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606854104 · Cited by 966
Senescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909
Cytokine regulation of endothelial cell function
Mantovani, A., Bussolino, F., & Dejana, E. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.8.1592209 · Cited by 678
Metadata
- Authors
- Maier, J. A. M., Voulalas, P., Roeder, D., & Maciag, T.
- Venue
- Science
- Published
- 1990-09-28
- Volume
- 249
- Issue
- 4976
- Pages
- 1570-1574
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004878760
- Cited by
- 397
- References
- 2
- FWCI
- 19.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maier, J. A. M., Voulalas, P., Roeder, D., & Maciag, T. (1990). Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1αAntisense Oligomer. Science. https://doi.org/10.1126/science.2218499
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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