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Mesodermal Control of Neural Cell Identity: Floor Plate Induction by the Notochord
Abstract
The floor plate is a specialized group of midline neuroepithelial cells that appears to regulate cell differentiation and axonal growth in the developing vertebrate nervous system. A floor plate-specific chemoattractant was used as a marker to examine the role of the notochord in avian floor plate development. Expression of this chemoattractant in lateral cells of the neural plate and neural tube was induced by an ectopic notochord, and midline neural tube cells did not express the chemoattractant after removal of the notochord early in development. These results provide evidence that a local signal from the notochord induces the functional properties of the floor plate.
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Cited by
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
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Walther, C., & Gruss, P. (1991) · Development · doi:10.1242/dev.113.4.1435 · Cited by 1,255
Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruiz i Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90514-2 · Cited by 854
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Ericson, J., Thor, S., Edlund, T., Jessell, T. M., & Yamada, T. (1992) · Science · doi:10.1126/science.1350865 · Cited by 620
Self-citationIdentification of intrinsic determinants of midbrain dopamine neurons
Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B., Perlmann, T., & Ericson, J. (2006) · Cell · doi:10.1016/j.cell.2005.10.037 · Cited by 587
Metadata
- Authors
- Placzek, M., Tessier-Lavigne, M., Yamada, T., Jessell, T., & Dodd, J.
- Venue
- Science
- Published
- 1990-11-16
- Volume
- 250
- Issue
- 4983
- Pages
- 985-988
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084981578
- Cited by
- 302
- References
- 0
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Placzek, M., Tessier-Lavigne, M., Yamada, T., Jessell, T., & Dodd, J. (1990). Mesodermal Control of Neural Cell Identity: Floor Plate Induction by the Notochord. Science. https://doi.org/10.1126/science.2237443
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
