The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
How Big Is the Universe of Exons?
Abstract
If genes have been assembled from exon subunits, the frequency with which exons are reused leads to an estimate of the size of the underlying exon universe. An exon database was constructed from available protein sequences, and homologous exons were identified on the basis of amino acid identity; statistically significant matches were determined by Monte Carlo methods. It is estimated that only 1000 to 7000 exons were needed to construct all proteins.
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Citations
Cites
Gilbert, W. (1978) · Nature · doi:10.1038/271501a0 · Cited by 2,300
Self-citationIndik, Z., Yeh, H., Ornstein-Goldstein, N., Sheppard, P., Anderson, N., Rosenbloom, J. C., Peltonen, L., & Rosenbloom, J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5680 · Cited by 334
Cited by
A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure
Bowie, J. U., Lüthy, R., & Eisenberg, D. (1991) · Science · doi:10.1126/science.1853201 · Cited by 2,851
The evolutionary origin of orphan genes
Tautz, D., & Domazet-Lošo, T. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3053 · Cited by 764
Protein folding dynamics: The diffusion‐collision model and experimental data
Karplus, M., & Weaver, D. L. (1994) · Protein Science · doi:10.1002/pro.5560030413 · Cited by 443
Identification and characterization of a novel cytoskeleton-associated pp60src substrate.
Wu, H., Reynolds, A. B., Kanner, S. B., Vines, R. R., & Parsons, J. T. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.10.5113 · Cited by 435
Genome evolution and the evolution of exon-shuffling — a review
Patthy, L. (1999) · Gene · doi:10.1016/s0378-1119(99)00228-0 · Cited by 422
Metadata
- Authors
- Dorit, R. L., Schoenbach, L., & Gilbert, W.
- Venue
- Science
- Published
- 1990-12-07
- Volume
- 250
- Issue
- 4986
- Pages
- 1377-1382
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980038204
- Cited by
- 231
- References
- 2
- FWCI
- 10.40
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
