The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Identification and characterization of a novel cytoskeleton-associated pp60src substrate.
Open accessAbstract
Transformation of cells by the src oncogene results in elevated tyrosine phosphorylation of two related proteins, p80 and p85 (p80/85). Immunostaining with specific monoclonal antibodies revealed a striking change of subcellular localization of p80/85 in src-transformed cells. p80/85 colocalizes with F-actin in peripheral extensions of normal cells and rosettes (podosomes) of src-transformed cells. Sequence analysis of cDNA clones encoding p80/85 revealed an amino-terminal domain composed of six copies of a direct tandem repeat, each repeat containing 37 amino acids, a carboxyl-terminal SH3 domain, and an interdomain region composed of a highly charged acidic region and a region rich in proline, serine, and threonine. The multidomain structure of p80/85 and its colocalization with F-actin in normal and src-transformed cells suggest that these proteins may associate with components of the cytoskeleton and contribute to organization of cell structure.
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Cited by
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Actin Assembly and Endocytosis: From Yeast to Mammals
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Metadata
- Authors
- Wu, H., Reynolds, A. B., Kanner, S. B., Vines, R. R., & Parsons, J. T.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1991-10
- Volume
- 11
- Issue
- 10
- Pages
- 5113-5124
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2162075350
- Cited by
- 435
- References
- 72
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Wu, H., Reynolds, A. B., Kanner, S. B., Vines, R. R., & Parsons, J. T. (1991). Identification and characterization of a novel cytoskeleton-associated pp60src substrate. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.11.10.5113
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
