The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
A Sign Inversion Mechanism for Enzymatic Supercoiling of DNA
Abstract
Both the introduction and the removal of supertwists by DNA gyrase change the linking number of DNA in steps of two. This surprising finding provides strong evidence that gyrase acts by a mechanism, called sign inversion, whereby a positive supercoil is directly inverted into a negative one via a transient double-strand break.
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Citations
Cites
DNA gyrase: an enzyme that introduces superhelical turns into DNA.
Gellert, M., Mizuuchi, K., O'Dea, M. H., & Nash, H. A. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.3872 · Cited by 1,204
Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity
Gellert, M., Mizuuchi, K., O'Dea, M. H., Itoh, T., & Tomizawa, J.-I. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.4772 · Cited by 833
Interaction between DNA and an Escherichia coli protein ω
Wang, J. C. (1971) · Journal of Molecular Biology · doi:10.1016/0022-2836(71)90334-2 · Cited by 786
Sugino, A., Peebles, C. L., Kreuzer, K. N., & Cozzarelli, N. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.4767 · Cited by 784
Self-citationConformational fluctuations of DNA helix.
Depew, D. E., & Wang, J. C. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4275 · Cited by 558
Energy coupling in DNA gyrase and the mechanism of action of novobiocin
Sugino, A., Higgins, N. P., Brown, P. O., Peebles, C. L., & Cozzarelli, N. R. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.4838 · Cited by 403
Self-citationSTRUCTURE AND REACTIONS OF CLOSED DUPLEX DNA
Bauer, W. R. (1978) · Annual Review of Biophysics and Bioengineering · doi:10.1146/annurev.bb.07.060178.001443 · Cited by 319
DNA gyrase: subunit structure and ATPase activity of the purified enzyme.
Mizuuchi, K., O'Dea, M. H., & Gellert, M. F. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.12.5960 · Cited by 292
Linking numbers and nucleosomes.
Crick, F. H. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.8.2639 · Cited by 288
Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA.
Liu, L. F., & Wang, J. C. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.5.2098 · Cited by 207
Cited by
DNA Topoisomerases: Structure, Function, and Mechanism
Champoux, J. J. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.369 · Cited by 2,743
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology
Schoeffler, A. J., & Berger, J. M. (2008) · Quarterly Reviews of Biophysics · doi:10.1017/s003358350800468x · Cited by 490
Topoisomerases as anticancer targets
Delgado, J. L., Hsieh, C.-M., Chan, N.-L., & Hiasa, H. (2018) · Biochemical Journal · doi:10.1042/bcj20160583 · Cited by 481
Reverse gyrase—a topoisomerase which introduces positive superhelical turns into DNA
Kikuchi, A., & Asai, K. (1984) · Nature · doi:10.1038/309677a0 · Cited by 292
Metadata
- Authors
- Brown, P. O., & Cozzarelli, N. R.
- Venue
- Science
- Published
- 1979-11-30
- Volume
- 206
- Issue
- 4422
- Pages
- 1081-1083
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972804002
- Cited by
- 332
- References
- 11
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
