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Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS
Abstract
Long-term cultures were established of HTLV-III-infected T4 cells from patients with the acquired immune deficiency syndrome (AIDS) and of T4 cells from normal donors after infection of the cells in vitro. By initially reducing the number of cells per milliliter of culture medium it was possible to grow the infected cells for 50 to 60 days. As with uninfected T cells, immunologic activation of the HTLV-III-infected cells with phytohemagglutinin led to patterns of gene expression typical of T-cell differentiation, such as production of interleukin-2 and expression of interleukin-2 receptors, but in the infected cells immunologic activation also led to expression of HTLV-III, which was followed by cell death. The results revealed a cytopathogenic mechanism that may account for T4 cell depletion in AIDS patients and suggest how repeated antigenic stimulation by infectious agents, such as malaria in Africa, or by allogeneic blood or semen, may be important determinants of the latency period in AIDS.
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Cites
Sodroski, J. G., Rosen, C. A., & Haseltine, W. A. (1984) · Science · doi:10.1126/science.6330891 · Cited by 770
Cited by
Zack, J. A., Arrigo, S. J., Weitsman, S. R., Go, A. S., Haislip, A., & Chen, I. S. Y. (1990) · Cell · doi:10.1016/0092-8674(90)90802-l · Cited by 1,517
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
Grilli, M., Chiu, J. J.-S., & Lenardo, M. J. (1993) · International Review of Cytology · doi:10.1016/s0074-7696(08)61873-2 · Cited by 936
Molecular Targets for AIDS Therapy
Mitsuya, H., Yarchoan, R., & Broder, S. (1990) · Science · doi:10.1126/science.1699273 · Cited by 732
A second post-transcriptional trans-activator gene required for HTLV-III replication
Sodroski, J., Goh, W. C., Rosen, C., Dayton, A., Terwilliger, E., & Haseltine, W. (1986) · Nature · doi:10.1038/321412a0 · Cited by 631
Ullman, K. S., Northrop, J. P., Verweij, C. L., & Crabtree, G. R. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.002225 · Cited by 503
Metadata
- Authors
- Zagury, D., Bernard, J., Leonard, R., Cheynier, R., Feldman, M., Sarin, P. S., & Gallo, R. C.
- Venue
- Science
- Published
- 1986-02-21
- Volume
- 231
- Issue
- 4740
- Pages
- 850-853
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2040681869
- Cited by
- 530
- References
- 1
- FWCI
- 16.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zagury, D., Bernard, J., Leonard, R., Cheynier, R., Feldman, M., Sarin, P. S., & Gallo, R. C. (1986). Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS. Science. https://doi.org/10.1126/science.2418502
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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