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Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor
Abstract
Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are structurally related peptides. Purified human TGF-α produced in Escherichia coli and pure natural mouse EGF were compared for their ability to bind to target cells in vitro and to promote angiogenesis in the hamster cheek pouch bioassay. Both polypeptides were found to bind in vitro to several target cells, including endothelial cells, and to stimulate their DNA synthesis in an equipotent fashion. In vivo, however, TGF-α was more potent than EGF in promoting angiogenesis and, because TGF-α is known to be secreted by a variety of human tumors, it is suggested that this growth factor may contribute to tumor-induced angiogenesis.
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Citations
Cited by
Folkman, J., & Klagsbrun, M. (1987) · Science · doi:10.1126/science.2432664 · Cited by 3,491
Mechanisms of normal and tumor-derived angiogenesis
Papetti, M., & Herman, I. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2001 · Cited by 809
Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.
Frank, S., Hübner, G., Breier, G., Longaker, M. T., Greenhalgh, D. G., & Werner, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.21.12607 · Cited by 764
Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
Kaur, B., Khwaja, F. W., Severson, E. A., Matheny, S. L., Brat, D. J., & Van Meir, E. G. (2005) · Neuro-Oncology · doi:10.1215/s1152851704001115 · Cited by 725
Transforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696
EGF and TGF‐α in wound healing and repair
Schultz, G., Clark, W., & Rotatori, D. S. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240450407 · Cited by 357
Biology of Interactions: Antiepidermal Growth Factor Receptor Agents
Harari, P. M., Allen, G. W., & Bonner, J. A. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.8984 · Cited by 214
Risau, W. (1990) · Progress in Growth Factor Research · doi:10.1016/0955-2235(90)90010-h · Cited by 145
MicroRNA-505 functions as a tumor suppressor in endometrial cancer by targeting TGF-α
Chen, S., Sun, K.-X., Liu, B.-L., Zong, Z.-H., & Zhao, Y. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0496-4 · Cited by 89
Metadata
- Authors
- Schreiber, A. B., Winkler, M. E., & Derynck, R.
- Venue
- Science
- Published
- 1986-06-06
- Volume
- 232
- Issue
- 4755
- Pages
- 1250-1253
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065418754
- Cited by
- 838
- References
- 0
- FWCI
- 18.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
