The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Caffeine-Induced Uncoupling of Mitosis from the Completion of DNA Replication in Mammalian Cells
Abstract
Caffeine was shown to induce mitotic events in mammalian cells before DNA replication (S phase) was completed. Synchronized BHK cells that were arrested in early S phase underwent premature chromosome condensation, nuclear envelope breakdown, morphological "rounding up," and mitosis-specific phosphoprotein synthesis when they were exposed to caffeine. These mitotic responses occurred only after the cells had entered S phase and only while DNA synthesis was inhibited by more than 70 percent. Inhibitors of protein synthesis blocked these caffeine-induced events, while inhibitors of RNA synthesis had little effect. These results suggest that caffeine induces the translation or stabilizes the protein product (or products) of mitosis-related RNA that accumulates in S-phase cells when DNA replication is suppressed. The ability to chemically manipulate the onset of mitosis should be useful for studying the regulation of this event in mammalian cells.
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Cites
Mammalian Cell Fusion : Induction of Premature Chromosome Condensation in Interphase Nuclei
JOHNSON, R. T., & RAO, P. N. (1970) · Nature · doi:10.1038/226717a0 · Cited by 701
Monoclonal antibodies to mitotic cells.
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GENETICS OF SOMATIC MAMMALIAN CELLS
Tjio, J. H., & Puck, T. T. (1958) · The Journal of Experimental Medicine · doi:10.1084/jem.108.2.259 · Cited by 402
Premature chromosome condensation in a ts DNA-mutant of BHK cells
Nishimoto, T., Eilen, E., & Basilico, C. (1978) · Cell · doi:10.1016/0092-8674(78)90017-x · Cited by 249
Effect of caffeine on DNA synthesis in irradiated and unirradiated mammalian cells
Painter, R. B. (1980) · Journal of Molecular Biology · doi:10.1016/0022-2836(80)90191-6 · Cited by 136
INDUCTION OF PROPHASE IN INTERPHASE NUCLEI BY FUSION WITH METAPHASE CELLS
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Cited by
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
Kaelin, W. G. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1691 · Cited by 1,379
Feedback control of mitosis in budding yeast
Li, R., & Murray, A. W. (1991) · Cell · doi:10.1016/0092-8674(81)90015-5 · Cited by 1,174
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951
Heald, R., McLoughlin, M., & McKeon, F. (1993) · Cell · doi:10.1016/0092-8674(93)80048-j · Cited by 462
Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage
Anderson, L., Henderson, C., & Adachi, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1719-1729.2001 · Cited by 367
Metadata
- Authors
- Schlegel, R., & Pardee, A. B.
- Venue
- Science
- Published
- 1986-06-06
- Volume
- 232
- Issue
- 4755
- Pages
- 1264-1266
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035143633
- Cited by
- 320
- References
- 7
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schlegel, R., & Pardee, A. B. (1986). Caffeine-Induced Uncoupling of Mitosis from the Completion of DNA Replication in Mammalian Cells. Science. https://doi.org/10.1126/science.2422760
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
