The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The Ninth Component of Complement and the Pore-Forming Protein (Perforin 1) from Cytotoxic T Cells: Structural, Immunological, and Functional Similarities
Abstract
The ninth component of complement (C9) and the pore-forming protein (PFP or perforin) from cytotoxic T lymphocytes polymerize to tubular lesions having an internal diameter of 100 Å and 160 Å, respectively, when bound to lipid bilayers. Polymerized C9, assembled by slow spontaneous or rapid Zn 2+ -induced polymerization, and polyperforin, which is assembled only in the presence of Ca 2+ , constitute large aqueous pores that are stable, nonselective for solutes, and insensitive to changes of membrane potential. Monospecific polyclonal antibodies to purified C9 and PFP show cross-reactivity, suggesting structural homology between the two molecules. The structural and functional homologies between these two killer molecules imply an active role for pore formation during cell lysis.
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Cited by
Perforin and granzymes: function, dysfunction and human pathology
Voskoboinik, I., Whisstock, J. C., & Trapani, J. A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3839 · Cited by 1,327
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Cell Death Mechanisms and the Immune System
Golstein, P., Ojcius, D. M., & Young, J. D. (1991) · Immunological Reviews · doi:10.1111/j.1600-065x.1991.tb00822.x · Cited by 447
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Metadata
- Authors
- Young, J. D.-E., Cohn, Z. A., & Podack, E. R.
- Venue
- Science
- Published
- 1986-07-11
- Volume
- 233
- Issue
- 4760
- Pages
- 184-190
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969746584
- Cited by
- 273
- References
- 31
- FWCI
- 13.41
- Type
- journal article
- Language
- en
- Open access
- closed
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