The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
HTLV-III/LAV-Neutralizing Antibodies to an E. coli -Produced Fragment of the Virus Envelope
Abstract
Immunization with either an Escherichia coli recombinant segment of the human T-cell lymphotropic virus (HTLV-III/LAV) envelope protein (gp120) or with deglycosylated gp120 envelope protein produced antibodies that neutralize HTLV-III/LAV infection in vitro. Virus neutralization titers of these antisera were equivalent to those obtained with purified native gp120 as immunogen. This localizes at least one class of neutralizing epitopes to the carboxyl-terminal half of the molecule. In addition, native gp120 prevented HTLV-III/LAV—mediated cell fusion, whereas the recombinant gp120 fragment did not. This shows that although glycosylation is not required for induction of neutralizing antibodies, it may be important for interaction with CD4, the virus receptor. A segment of the HTLV-III/LAV envelope produced in E. coli may be an important ingredient of a vaccine for acquired immune deficiency syndrome.
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Starcich, B. R., Hahn, B. H., Shaw, G. M., McNeely, P. D., Modrow, S., Wolf, H., Parks, E. S., Parks, W. P., Josephs, S. F., Gallo, R. C., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90778-6 · Cited by 767
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Cited by
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
Uversky, V. N., Oldfield, C. J., & Dunker, A. K. (2005) · Journal of Molecular Recognition · doi:10.1002/jmr.747 · Cited by 847
Thali, M., Moore, J. P., Furman, C., Charles, M., Ho, D. D., Robinson, J., & Sodroski, J. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.3978-3988.1993 · Cited by 616
Wyatt, R., Moore, J., Accola, M., Desjardin, E., Robinson, J., & Sodroski, J. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5723-5733.1995 · Cited by 417
Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1
Javaherian, K., Langlois, A. J., LaRosa, G. J., Profy, A. T., Bolognesi, D. P., Herlihy, W. C., Putney, S. D., & Matthews, T. J. (1990) · Science · doi:10.1126/science.1703322 · Cited by 353
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Metadata
- Authors
- Putney, S. D., Matthews, T. J., Robey, W. G., Lynn, D. L., Robert-Guroff, M., Mueller, W. T., Langlois, A. J., Ghrayeb, J., Petteway, S. R., Weinhold, K. J., Fischinger, P. J., Wong-Staal, F., Gallo, R. C., & Bolognesi, D. P.
- Venue
- Science
- Published
- 1986-12-12
- Volume
- 234
- Issue
- 4782
- Pages
- 1392-1395
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027559384
- Cited by
- 332
- References
- 1
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Putney, S. D., Matthews, T. J., Robey, W. G., Lynn, D. L., Robert-Guroff, M., Mueller, W. T., Langlois, A. J., Ghrayeb, J., Petteway, S. R., Weinhold, K. J., Fischinger, P. J., Wong-Staal, F., Gallo, R. C., & Bolognesi, D. P. (1986). HTLV-III/LAV-Neutralizing Antibodies to an E. coli -Produced Fragment of the Virus Envelope. Science. https://doi.org/10.1126/science.2431482
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
