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The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells
Abstract
Macrophages handle extracellular proteins and secrete diverse bioactive molecules and, therefore, influence the physiology of many tissues. They also have an important immunoregulatory role. The immune response to proteins involves the activation of the T helper subset of lymphocytes. The T helper cell is activated only when it interacts with the protein displayed on the surface of a macrophage or other accessory cell. This interaction involves restrictive proteins encoded in the major histocompatibility gene complex as well as growth-differentiating proteins.
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Citations
Cited by
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,098
Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes
Lotz, M., Vaughan, J. H., & Carson, D. A. (1988) · Science · doi:10.1126/science.2457950 · Cited by 915
Johnston, R. B. (1988) · New England Journal of Medicine · doi:10.1056/nejm198803243181205 · Cited by 699
Ahsan, F. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00549-1 · Cited by 570
Israël, A., Le Bail, O., Hatat, D., Piette, J., Kieran, M., Logeat, F., Wallach, D., Fellous, M., & Kourilsky, P. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08556.x · Cited by 271
Metadata
- Authors
- Unanue, E. R., & Allen, P. M.
- Venue
- Science
- Published
- 1987-05
- Volume
- 236
- Issue
- 4801
- Pages
- 551-557
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014042634
- Cited by
- 1,021
- References
- 0
- FWCI
- 47.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Unanue, E. R., & Allen, P. M. (1987). The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells. Science. https://doi.org/10.1126/science.2437650
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
