The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Effect of Membrane Potential Changes on the Calcium Transient in Single Rat Cardiac Muscle Cells
Abstract
The mechanism that links membrane potential changes to the release of calcium from internal stores to cause contraction of cardiac cells is unclear. By using the calcium indicator fura-2 under voltage-clamp conditions, changes in intracellular calcium could be monitored in single rat ventricular cells while controlling membrane potential. The voltage dependence of the depolarization-induced increase in intracellular calcium was not the same as that of the calcium current ( I si ), which suggests that only a small fraction of I si is required to trigger calcium release from the sarcoplasmic reticulum. In addition, sarcoplasmic reticulum calcium release may be partly regulated by membrane potential, since repolarization could terminate the rise in intracellular calcium. Thus, changes in the action potential will have immediate effects on the time course of the calcium transient beyond those associated with its effects on I si .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,607
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Fabiato, A. (1985) · The Journal of general physiology · doi:10.1085/jgp.85.2.247 · Cited by 892
A novel type of cardiac calcium channel in ventricular cells
Nilius, B., Hess, P., Lansman, J. B., & Tsien, R. W. (1985) · Nature · doi:10.1038/316443a0 · Cited by 738
Bean, B. P. (1985) · The Journal of general physiology · doi:10.1085/jgp.86.1.1 · Cited by 717
Fabiato, A., & Fabiato, F. (1975) · The Journal of Physiology · doi:10.1113/jphysiol.1975.sp011026 · Cited by 683
Williams, D. A., Fogarty, K. E., Tsien, R. Y., & Fay, F. S. (1985) · Nature · doi:10.1038/318558a0 · Cited by 657
Measurement of Ca2+ concentrations in living cells
Blinks, J. R., Wier, W. G., Hess, P., & Prendergast, F. G. (1982) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(82)90011-6 · Cited by 654
The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle.
Allen, D. G., & Kurihara, S. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014221 · Cited by 556
Fabiato, A. (1985) · The Journal of general physiology · doi:10.1085/jgp.85.2.291 · Cited by 444
Cited by
Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure
Gómez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., & Lederer, W. J. (1997) · Science · doi:10.1126/science.276.5313.800 · Cited by 758
Self-citationBeuckelmann, D. J., Näbauer, M., & Erdmann, E. (1992) · Circulation · doi:10.1161/01.cir.85.3.1046 · Cited by 600
Sodium Current-Induced Release of Calcium from Cardiac Sarcoplasmic Reticulum
Leblanc, N., & Hume, J. R. (1990) · Science · doi:10.1126/science.2158146 · Cited by 554
Thayer, S. A., & Miller, R. J. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018094 · Cited by 403
Naruse, K., & Sokabe, M. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.4.c1037 · Cited by 283
Metadata
- Authors
- Cannell, M. B., Berlin, J. R., & Lederer, W. J.
- Venue
- Science
- Published
- 1987-12-04
- Volume
- 238
- Issue
- 4832
- Pages
- 1419-1423
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090803944
- Cited by
- 353
- References
- 25
- FWCI
- 19.80
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of Membrane Potential Changes on the Calcium Transient in Single Rat Cardiac Muscle Cells. https://app.cochat.ai/papers/10.1126/science.2446391
- The paper
- Cannell, M. B., Berlin, J. R., & Lederer, W. J. (1987). Effect of Membrane Potential Changes on the Calcium Transient in Single Rat Cardiac Muscle Cells. Science. https://doi.org/10.1126/science.2446391
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
