The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure
Abstract
Cardiac hypertrophy and heart failure caused by high blood pressure were studied in single myocytes taken from hypertensive rats (Dahl SS/Jr) and SH-HF rats in heart failure. Confocal microscopy and patch-clamp methods were used to examine excitation-contraction (EC) coupling, and the relation between the plasma membrane calcium current ( I Ca ) and evoked calcium release from the sarcoplasmic reticulum (SR), which was visualized as “calcium sparks.” The ability of I Ca to trigger calcium release from the SR in both hypertrophied and failing hearts was reduced. Because I Ca density and SR calcium-release channels were normal, the defect appears to reside in a change in the relation between SR calcium-release channels and sarcolemmal calcium channels. β-Adrenergic stimulation largely overcame the defect in hypertrophic but not failing heart cells. Thus, the same defect in EC coupling that develops during hypertrophy may contribute to heart failure when compensatory mechanisms fail.
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Cites
Heart Disease: A Textbook of Cardiovascular Medicine.
(1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-3-415_3 · Cited by 4,109
Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle
Cheng, H., Lederer, W. J., & Cannell, M. B. (1993) · Science · doi:10.1126/science.8235594 · Cited by 1,935
Self-citationHypertension : pathophysiology, diagnosis, and management
Laragh, J. H., & Brenner, B. M. (1995) · Raven Press eBooks · Cited by 1,932
Excitation-Contraction Coupling and Cardiac Contractile Force
Bers, D. M., & Zhu, Y. (2010) · Journal of Cardiovascular Disease Research · doi:10.1016/s0975-3583(10)11011-0 · Cited by 1,603
Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor
Chua, S. C., Chung, W. K., Wu-Peng, X. S., Zhang, Y., Liu, S.-M., Tartaglia, L., & Leibel, R. L. (1996) · Science · doi:10.1126/science.271.5251.994 · Cited by 1,075
Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells
McDonald, T. F., Pelzer, S., Trautwein, W., & Pelzer, D. J. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.2.365 · Cited by 995
JBeuckelmann, D., MNäbauer, & EErdmann (1992) · Circulation · Cited by 662
Theory of excitation-contraction coupling in cardiac muscle
Stern, M. D. (1992) · Biophysical Journal · doi:10.1016/s0006-3495(92)81615-6 · Cited by 651
Beuckelmann, D. J., Näbauer, M., & Erdmann, E. (1992) · Circulation · doi:10.1161/01.cir.85.3.1046 · Cited by 600
Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes
Bassani, J. W., Yuan, W., & Bers, D. M. (1995) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1995.268.5.c1313 · Cited by 547
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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
Mohler, P. J., Schott, J.-J., Gramolini, A. O., Dilly, K. W., Guatimosim, S., duBell, W. H., Song, L.-S., Haurogné, K., Kyndt, F., Ali, M. E., et al. (2003) · Nature · doi:10.1038/nature01335 · Cited by 957
Self-citationThe machineries, regulation and cellular functions of mitochondrial calcium
Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941
Calmodulin kinase II inhibition protects against structural heart disease
Zhang, R., Khoo, M. S. C., Wu, Y., Yang, Y., Grueter, C. E., Ni, G., Price, E. E., Thiel, W., Guatimosim, S., Song, L.-S., et al. (2005) · Nature Medicine · doi:10.1038/nm1215 · Cited by 579
Self-citationEngineered In Vitro Disease Models
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554
Metadata
- Authors
- Gómez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., & Lederer, W. J.
- Venue
- Science
- Published
- 1997-05-02
- Volume
- 276
- Issue
- 5313
- Pages
- 800-806
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036424054
- Cited by
- 758
- References
- 38
- FWCI
- 37.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure. https://app.cochat.ai/papers/10.1126/science.276.5313.800
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- Gómez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., & Lederer, W. J. (1997). Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure. Science. https://doi.org/10.1126/science.276.5313.800
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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