The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Reshaping Human Antibodies: Grafting an Antilysozyme Activity
Abstract
The production of therapeutic human monoclonal antibodies by hybridoma technology has proved difficult, and this has prompted the "humanizing" of mouse monoclonal antibodies by recombinant DNA techniques. It was shown previously that the binding site for a small hapten could be grafted from the heavy-chain variable domain of a mouse antibody to that of a human myeloma protein by transplanting the hypervariable loops. It is now shown that a large binding site for a protein antigen (lysozyme) can also be transplanted from mouse to human heavy chain. The success of such constructions may be facilitated by an induced-fit mechanism.
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Cites
Replacing the complementarity-determining regions in a human antibody with those from a mouse
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Self-citationCanonical structures for the hypervariable regions of immunoglobulins
Chothia, C., & Lesk, A. M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90412-8 · Cited by 1,406
Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution
Amit, A. G., Mariuzza, R. A., Phillips, S. E. V., & Poljak, R. J. (1986) · Science · doi:10.1126/science.2426778 · Cited by 1,182
Hydrogen bonding and biological specificity analysed by protein engineering
Fersht, A. R., Shi, J.-P., Knill-Jones, J., Lowe, D. M., Wilkinson, A. J., Blow, D. M., Brick, P., Carter, P., Waye, M. M. Y., & Winter, G. (1985) · Nature · doi:10.1038/314235a0 · Cited by 1,056
Self-citationChimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.
Morrison, S. L., Johnson, M. J., Herzenberg, L. A., & Oi, V. T. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.21.6851 · Cited by 1,039
Potter, H., Weir, L., & Leder, P. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.22.7161 · Cited by 866
Three-dimensional structure of a complex of antibody with influenza virus neuraminidase
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Improved oligonudeotide site-directed rautagenesis using M13 vectors
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Self-citationDomain association in immunoglobulin molecules
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Cited by
Humanization of an anti-p185HER2 antibody for human cancer therapy.
Carter, P., Presta, L., Gorman, C. M., Ridgway, J. B., Henner, D., Wong, W. L., Rowland, A. M., Kotts, C., Carver, M. E., & Shepard, H. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4285 · Cited by 1,918
Improving the efficacy of antibody-based cancer therapies
Carter, P. (2001) · Nature Reviews Cancer · doi:10.1038/35101072 · Cited by 833
The structural basis of antibody–antigen recognition
Sela-Culang, I., Kunik, V., & Ofran, Y. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00302 · Cited by 530
Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex.
Padlan, E. A., Silverton, E. W., Sheriff, S., Cohen, G. H., Smith-Gill, S. J., & Davies, D. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5938 · Cited by 458
High Level Escherichia coli Expression and Production of a Bivalent Humanized Antibody Fragment
Carter, P., Kelley, R. F., Rodrigues, M. L., Snedecor, B., Covarrubias, M., Velligan, M. D., Wong, W. L. T., Rowland, A. M., Kotts, C. E., Carver, M. E., et al. (1992) · Nature Biotechnology · doi:10.1038/nbt0292-163 · Cited by 330
Metadata
- Authors
- Verhoeyen, M., Milstein, C., & Winter, G.
- Venue
- Science
- Published
- 1988-03-25
- Volume
- 239
- Issue
- 4847
- Pages
- 1534-1536
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971142781
- Cited by
- 345
- References
- 16
- FWCI
- 27.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
