The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Amiloride Selectively Blocks the Low Threshold (T) Calcium Channel
Abstract
More than one type of voltage-gated calcium channel has been identified in muscle cells and neurons. Many specific organic and inorganic blockers of the conventional, slowly inactivating high threshold (L) calcium channel have been reported. No specific blockers of the low threshold (T) channel have been as yet identified. Amiloride, a potassium sparing diuretic, has now been shown to selectively block the low threshold calcium channel in mouse neuroblastoma and chick dorsal root ganglion neurons. The selective blockade of the T-type calcium channel will allow identification of this channel in different tissues and characterization of its specific physiological role.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
Antzelevitch, C., Sicouri, S., Litovsky, S. H., Lukas, A., Krishnan, S. C., Di Diego, J. M., Gintant, G. A., & Liu, D. W. (1991) · Circulation Research · doi:10.1161/01.res.69.6.1427 · Cited by 734
Halothane blocks low-voltage-activated calcium current in rat sensory neurons
Takenoshita, M., & Steinbach, J. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-05-01404.1991 · Cited by 69
Metadata
- Authors
- Tang, C.-M., Presser, F., & Morad, M.
- Venue
- Science
- Published
- 1988-04-08
- Volume
- 240
- Issue
- 4849
- Pages
- 213-215
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082096533
- Cited by
- 390
- References
- 1
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
